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Mouse Anti-RFX6 Recombinant Antibody (811704) (CBMAB-R2387-CN)

This product is a Mouse antibody that recognizes RFX6. The antibody 811704 can be used for immunoassay techniques such as: WB.
See all RFX6 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
811704
Antibody Isotype
IgG2b
Application
WB

Basic Information

Immunogen
E. coli-derived recombinant human RFX6, Lys324-Thr511, Accession # Q8HWS3
Specificity
Human
Antibody Isotype
IgG2b
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
LYOPH
Buffer
PBS, Trehalose
Concentration
LYOPH

Target

Full Name
RFX6
Introduction
The nuclear protein encoded by this gene is a member of the regulatory factor X (RFX) family of transcription factors. Studies in mice suggest that this gene is specifically required for the differentiation of islet cells for the production of insulin, but not for the differentiation of pancreatic polypeptide-producing cells. It regulates the transcription factors involved in beta-cell maturation and function, thus, restricting the expression of the beta-cell differentiation and specification genes. Mutations in this gene are associated with Mitchell-Riley syndrome, which is characterized by neonatal diabetes with pancreatic hypoplasia, duodenal and jejunal atresia, and gall bladder agenesis. [provided by RefSeq, Sep 2010]
Entrez Gene ID
222546
UniProt ID
Q8HWS3
Alternative Names
Regulatory Factor X6; Regulatory Factor X Domain-Containing Protein 1; DNA-Binding Protein RFX6; Regulatory Factor X, 6; RFXDC1; Regulatory Factor X Domain Containing 1;
Function
Transcription factor required to direct islet cell differentiation during endocrine pancreas development. Specifically required for the differentiation of 4 of the 5 islet cell types and for the production of insulin (PubMed:20148032, PubMed:25497100).
Not required for pancreatic PP (polypeptide-producing) cells differentiation. Acts downstream of NEUROG3 and regulates the transcription factors involved in beta-cell maturation and function, thereby restricting the expression of the beta-cell differentiation and specification genes, and thus the beta-cell fate choice. Activates transcription by forming a heterodimer with RFX3 and binding to the X-box in the promoter of target genes (PubMed:20148032).
Involved in glucose-stimulated insulin secretion by promoting insulin and L-type calcium channel gene transcription (PubMed:25497100).
Biological Process
Biological Process endocrine pancreas developmentManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process glucose homeostasisManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process pancreatic A cell differentiationISS:UniProtKB
Biological Process pancreatic D cell differentiationISS:UniProtKB
Biological Process pancreatic epsilon cell differentiationISS:UniProtKB
Biological Process positive regulation of insulin secretion involved in cellular response to glucose stimulusManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process positive regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIDA:NTNU_SB
Biological Process positive regulation of transcription, DNA-templatedManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process regulation of insulin secretionManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIBA:GO_Central
Biological Process type B pancreatic cell differentiationISS:UniProtKB
Cellular Location
Nucleus
Involvement in disease
Mitchell-Riley syndrome (MTCHRS):
A disorder characterized by neonatal diabetes, hypoplastic or annular pancreas, duodenal and jejunal atresia, and absent gallbladder. There is no dysmorphic features.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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