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Mouse Anti-RGS17 Recombinant Antibody (2H4) (CBMAB-R2445-CN)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
2H4
Antibody Isotype
IgM, κ
Application
ELISA, WB

Basic Information

Immunogen
Full-length recombinant corresponding to aa. 1-210 from human RGS17 with GST tag
Specificity
Human
Antibody Isotype
IgM, κ
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
Ascites

Target

Full Name
Regulator Of G Protein Signaling 17
Introduction
This gene encodes a member of the regulator of G-protein signaling family. This protein contains a conserved, 120 amino acid motif called the RGS domain and a cysteine-rich region. The protein attenuates the signaling activity of G-proteins by binding to activated, GTP-bound G alpha subunits and acting as a GTPase activating protein (GAP), increasing the rate of conversion of the GTP to GDP. This hydrolysis allows the G alpha subunits to bind G beta/gamma subunit heterodimers, forming inactive G-protein heterotrimers, thereby terminating the signal. [provided by RefSeq, Jul 2008]
Entrez Gene ID
26575
UniProt ID
Q9UGC6
Alternative Names
Regulator Of G Protein Signaling 17; Regulator Of G-Protein Signaling 17; RGSZ2; Regulator Of G-Protein Signalling 17; RGS-17; HRGS17;
Function
Regulates G protein-coupled receptor signaling cascades, including signaling via muscarinic acetylcholine receptor CHRM2 and dopamine receptor DRD2. Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form (PubMed:15096504).
Binds selectively to GNAZ and GNAI2 subunits, accelerates their GTPase activity and regulates their signaling activities. Negatively regulates mu-opioid receptor-mediated activation of the G-proteins (By similarity).
Biological Process
Biological Process G protein-coupled receptor signaling pathwayTAS:Reactome
Biological Process negative regulation of signal transductionIEA:UniProtKB-KW
Cellular Location
Membrane
Synapse, synaptosome
Nucleus
Cytoplasm
PTM
N- and O-glycosylated in synapsomal membranes.
Serine phosphorylated in synapsomal membranes.
Sumoylated with SUMO1 and SUM02 in synaptosomes. The sumoylated forms act as a scaffold for sequestering mu-opioid receptor-activated G(alpha) subunits (By similarity).
Desumoylated by HINT1 (By similarity).
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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