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Mouse Anti-RGS18 Recombinant Antibody (1H6) (CBMAB-R2447-CN)

This product is a Mouse antibody that recognizes RGS18. The antibody 1H6 can be used for immunoassay techniques such as: ELISA, WB.
See all RGS18 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
1H6
Antibody Isotype
IgG
Application
ELISA, WB

Basic Information

Immunogen
Full length recombinant corresponding to aa. 1-236 from RGS18 (H20632) with GST tag
Specificity
Human
Antibody Isotype
IgG
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
Ascites

Target

Full Name
regulator of G-protein signaling 18
Introduction
This gene encodes a member of the regulator of G-protein signaling family. This protein is contains a conserved, 120 amino acid motif called the RGS domain. The protein attenuates the signaling activity of G-proteins by binding to activated, GTP-bound G alpha subunits and acting as a GTPase activating protein (GAP), increasing the rate of conversion of the GTP to GDP. This hydrolysis allows the G alpha subunits to bind G beta/gamma subunit heterodimers, forming inactive G-protein heterotrimers, thereby terminating the signal. Alternate transcriptional splice variants of this gene have been observed but have not been thoroughly characterized. [provided by RefSeq, Jul 2008]
Entrez Gene ID
64407
UniProt ID
Q9NS28
Alternative Names
Regulator Of G Protein Signaling 18; Regulator Of G-Protein Signalling 18; Regulator Of G-Protein Signaling 18; RGS13; Regulator Of G-Protein Signalling 13;
Function
Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G(i) alpha-1, G(i) alpha-2, G(i) alpha-3 and G(q) alpha.
Biological Process
Biological Process G protein-coupled receptor signaling pathwayTAS:Reactome
Biological Process negative regulation of signal transductionIEA:UniProtKB-KW
Biological Process regulation of G protein-coupled receptor signaling pathwayIEA:Ensembl
Cellular Location
Cytoplasm
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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