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Mouse Anti-RGS8 Recombinant Antibody (F-3) (CBMAB-R2468-CN)

This product is a Mouse antibody that recognizes RGS8. The antibody F-3 can be used for immunoassay techniques such as: WB, IP, IF, ELISA.
See all RGS8 antibodies

Summary

Host Animal
Mouse
Specificity
Mouse, Rat, Human
Clone
F-3
Application
WB, IP, IF, ELISA

Basic Information

Specificity
Mouse, Rat, Human
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Target

Full Name
Regulator Of G Protein Signaling 8
Introduction
This gene is a member of the regulator of G protein signaling (RGS) family and encodes a protein with a single RGS domain. Regulator of G protein signaling (RGS) proteins are regulatory and structural components of G protein-coupled receptor complexes. They accelerate transit through the cycle of GTP binding and hydrolysis to GDP, thereby terminating signal transduction, but paradoxically, also accelerate receptor-stimulated activation. [provided by RefSeq, Jul 2008]
Entrez Gene ID
Human85397
Mouse67792
Rat54297
UniProt ID
HumanP57771
MouseQ8BXT1
RatP49804
Alternative Names
Regulator Of G Protein Signaling 8; Regulator Of G-Protein Signalling 8; Regulator Of G-Protein Signaling 8;
Function
Regulates G protein-coupled receptor signaling cascades, including signaling via muscarinic acetylcholine receptor CHRM2 and dopamine receptor DRD2 (By similarity).
Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits, thereby driving them into their inactive GDP-bound form (PubMed:18434541).
Modulates the activity of potassium channels that are activated in response to DRD2 and CHRM2 signaling (By similarity).
Biological Process
Biological Process G protein-coupled acetylcholine receptor signaling pathwayISS:UniProtKB
Biological Process G protein-coupled receptor signaling pathwayTAS:Reactome
Biological Process negative regulation of signal transductionIEA:UniProtKB-KW
Biological Process positive regulation of GTPase activityManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process regulation of dopamine receptor signaling pathwayISS:UniProtKB
Cellular Location
Cell membrane
Membrane
Perikaryon
Cell projection, dendrite
Nucleus
Detected in Purkinje cell soma and dendrites. Associated with Purkinje cell membranes. Not detected in Purkinje cell nuclei. Detected in the nucleus after heterologous expression. Recruited to the cell membrane in the presence of GNAO1.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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