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Mouse Anti-RHCG Recombinant Antibody (5A4) (CBMAB-R2506-CN)


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Summary

Host Animal
Mouse
Specificity
Human, Rat
Clone
5A4
Antibody Isotype
IgG2a, κ
Application
ELISA, IHC, WB

Basic Information

Immunogen
Partial recombinant corresponding to aa. 418-480 from human RHCG (NP_057405) with GST tag
Specificity
Human, Rat
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.2

Target

Full Name
Rh family, C glycoprotein
Introduction
RHCG (Rh Family C Glycoprotein) is a Protein Coding gene. Diseases associated with RHCG include Retinohepatoendocrinologic Syndrome and Acute Urate Nephropathy. Among its related pathways are Transport of glucose and other sugars, bile salts and organic acids, metal ions and amine compounds. Gene Ontology (GO) annotations related to this gene include ankyrin binding and ammonium transmembrane transporter activity. An important paralog of this gene is RHBG.
Entrez Gene ID
Human51458
Rat293048
UniProt ID
HumanQ9UBD6
RatQ7TNN9
Alternative Names
Rh Family C Glycoprotein; Rhesus Blood Group Family Type C Glycoprotein; Rhesus Blood Group, C Glycoprotein; Rh Family Type C Glycoprotein; Tumor-Related Protein DRC2; Rh Glycoprotein Kidney; Rh Type C Glycoprotein; C15orf6;
Function
Functions as an electroneutral and bidirectional ammonium transporter. May regulate transepithelial ammonia secretion.
Biological Process
Biological Process amine transport1 PublicationNAS:UniProtKB
Biological Process ammonium homeostasisManual Assertion Based On ExperimentIBA:GO_Central
Biological Process ammonium transmembrane transportManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process cellular ion homeostasisManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process epithelial cell differentiation1 PublicationNAS:UniProtKB
Biological Process homeostatic process1 PublicationNAS:UniProtKB
Biological Process regulation of pHIEA:Ensembl
Biological Process transepithelial ammonium transportManual Assertion Based On ExperimentIDA:UniProtKB
Cellular Location
Apical cell membrane
Also detected at the basolateral membrane and in subapical vesicles.
Topology
Cytoplasmic: 1-9
Helical: 10-30
Extracellular: 31-60
Helical: 61-81
Cytoplasmic: 82-85
Helical: 86-106
Extracellular: 107-123
Helical: 124-144
Cytoplasmic: 145-148
Helical: 149-169
Extracellular: 170-177
Helical: 178-200
Cytoplasmic: 201-218
Helical: 219-239
Extracellular: 240-250
Helical: 251-271
Cytoplasmic: 272-281
Helical: 282-302
Extracellular: 303
Helical: 304-324
Cytoplasmic: 325-345
Helical: 346-366
Extracellular: 367-394
Helical: 395-415
Cytoplasmic: 416-479
PTM
N-glycosylated.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

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