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Mouse Anti-RHOBTB2 Recombinant Antibody (G-12) (CBMAB-D2230-YC)

Provided herein is a Mouse monoclonal antibody, which binds to Rho Related BTB Domain Containing 2 (RHOBTB2). The antibody can be used for immunoassay techniques, such as WB, IP, IF, ELISA.
See all RHOBTB2 antibodies

Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat
Clone
G-12
Antibody Isotype
IgG
Application
WB, IP, IF, ELISA

Basic Information

Specificity
Human, Mouse, Rat
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Rho-related BTB domain containing 2
Introduction
RHOBTB2 is a small Rho GTPase and a candidate tumor suppressor. The protein interacts with the cullin-3 protein, a ubiquitin E3 ligase necessary for mitotic cell division. This protein inhibits the growth and spread of some types of breast cancer. Three transcript variants encoding different isoforms have been found for this gene.
Entrez Gene ID
Human23221
Mouse246710
Rat306004
UniProt ID
HumanQ9BYZ6
MouseQ91V93
RatF7FCC0
Alternative Names
Rho Related BTB Domain Containing 2; Deleted In Breast Cancer 2 Gene Protein; DBC2; P83; Rho-Related BTB Domain-Containing Protein 2; Rho-Related BTB Domain Containing 2; KIAA0717;
Biological Process
Biological Process actin filament organizationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process cortical cytoskeleton organizationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process engulfment of apoptotic cellManual Assertion Based On ExperimentIBA:GO_Central
Biological Process establishment or maintenance of cell polarityManual Assertion Based On ExperimentIBA:GO_Central
Biological Process regulation of actin cytoskeleton organizationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process regulation of cell shapeManual Assertion Based On ExperimentIBA:GO_Central
Biological Process small GTPase mediated signal transductionIEA:InterPro
Cellular Location
cell cortex
cell projection
cytoplasmic vesicle
cytoskeleton
endosome membrane
plasma membrane
Involvement in disease
Developmental and epileptic encephalopathy 64 (DEE64):
A form of epileptic encephalopathy, a heterogeneous group of severe early-onset epilepsies characterized by refractory seizures, neurodevelopmental impairment, and poor prognosis. Development is normal prior to seizure onset, after which cognitive and motor delays become apparent. DEE64 is an autosomal dominant form characterized by onset of seizures usually in the first year of life. Seizure types are variable and include focal dyscognitive and generalized tonic-clonic seizures, as well as febrile seizures in the mildest affected individuals. Seizures tend to respond to medical treatment.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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