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Mouse Anti-RIT1 Recombinant Antibody (14G7) (CBMAB-R2763-CN)

This product is a Mouse antibody that recognizes RIT1. The antibody 14G7 can be used for immunoassay techniques such as: WB.
See all RIT1 antibodies

Summary

Host Animal
Mouse
Specificity
Mouse, Human
Clone
14G7
Antibody Isotype
IgG1
Application
WB

Basic Information

Specificity
Mouse, Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Concentration
1 mg/mL

Target

Full Name
Ras Like Without CAAX 1
Introduction
This gene encodes a member of a subfamily of Ras-related GTPases. The encoded protein is involved in regulating p38 MAPK-dependent signaling cascades related to cellular stress. This protein also cooperates with nerve growth factor to promote neuronal development and regeneration. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Feb 2012]
Entrez Gene ID
Human6016
Mouse19769
UniProt ID
HumanQ92963
MouseP70426
Alternative Names
Ras Like Without CAAX 1; Ras-Like Protein Expressed In Many Tissues; Ric-Like, Expressed In Many Tissues; Ras-Like Without CAAX Protein 1; GTP-Binding Protein Roc1; ROC1;
Function
Plays a crucial role in coupling NGF stimulation to the activation of both EPHB2 and MAPK14 signaling pathways and in NGF-dependent neuronal differentiation. Involved in ELK1 transactivation through the Ras-MAPK signaling cascade that mediates a wide variety of cellular functions, including cell proliferation, survival, and differentiation.
Biological Process
Biological Process Ras protein signal transductionManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process signal transductionManual Assertion Based On ExperimentTAS:ProtInc
Cellular Location
Cell membrane
Involvement in disease
Noonan syndrome 8 (NS8):
A form of Noonan syndrome, a disease characterized by short stature, facial dysmorphic features such as hypertelorism, a downward eyeslant and low-set posteriorly rotated ears, and a high incidence of congenital heart defects and hypertrophic cardiomyopathy. Other features can include a short neck with webbing or redundancy of skin, deafness, motor delay, variable intellectual deficits, multiple skeletal defects, cryptorchidism, and bleeding diathesis. Individuals with Noonan syndrome are at risk of juvenile myelomonocytic leukemia, a myeloproliferative disorder characterized by excessive production of myelomonocytic cells.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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