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Mouse Anti-RLIM Recombinant Antibody (1G10) (CBMAB-R2800-CN)

This product is a Mouse antibody that recognizes RLIM. The antibody 1G10 can be used for immunoassay techniques such as: ELISA, IF, IP, WB.
See all RLIM antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
1G10
Antibody Isotype
IgG2a, κ
Application
ELISA, IF, IP, WB

Basic Information

Immunogen
Partial recombinant corresponding to aa. 1-84 from human RNF12 (NP_057204) with GST tag
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.2

Target

Full Name
Ring finger protein, LIM domain interacting
Introduction
The protein encoded by this gene is a RING-H2 zinc finger protein. It has been shown to be an E3 ubiquitin protein ligase that targets LIM domain binding 1 (LDB1/CLIM), and causes proteasome-dependent degradation of LDB1. This protein and LDB1 are co-repressors of LHX1/LIM-1, a homeodomain transcription factor. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Feb 2009]
Entrez Gene ID
51132
UniProt ID
Q9NVW2
Alternative Names
Ring Finger Protein, LIM Domain Interacting; LIM Domain-Interacting RING Finger Protein; Ring Zinc Finger Protein NY-REN-43antigen; RING-Type E3 Ubiquitin Transferase RLIM; RING Finger LIM Domain-Binding Protein; Renal Carcinoma Antigen NY-REN-43; E3 Ubiquitin-Protein Ligase RLIM; Ring Finger Protein 12; RNF12; R-LIM;
Function
E3 ubiquitin-protein ligase. Acts as a negative coregulator for LIM homeodomain transcription factors by mediating the ubiquitination and subsequent degradation of LIM cofactors LDB1 and LDB2 and by mediating the recruitment the SIN3a/histone deacetylase corepressor complex. Ubiquitination and degradation of LIM cofactors LDB1 and LDB2 allows DNA-bound LIM homeodomain transcription factors to interact with other protein partners such as RLIM. Plays a role in telomere length-mediated growth suppression by mediating the ubiquitination and degradation of TERF1. By targeting ZFP42 for degradation, acts as an activator of random inactivation of X chromosome in the embryo, a stochastic process in which one X chromosome is inactivated to minimize sex-related dosage differences of X-encoded genes in somatic cells of female placental mammals.
Biological Process
Biological Process negative regulation of DNA-binding transcription factor activityIEA:Ensembl
Biological Process negative regulation of transcription by RNA polymerase IIIEA:Ensembl
Biological Process negative regulation of transcription, DNA-templated1 PublicationNAS:UniProtKB
Biological Process protein ubiquitinationISS:UniProtKB
Biological Process random inactivation of X chromosomeManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process regulation of dosage compensation by inactivation of X chromosomeManual Assertion Based On ExperimentIBA:GO_Central
Biological Process ubiquitin-dependent protein catabolic processISS:UniProtKB
Cellular Location
Nucleus
Involvement in disease
Tonne-Kalscheuer syndrome (TOKAS):
An X-linked recessive disorder characterized by global developmental delay apparent from early infancy, impaired intellectual development, speech delay, behavioral abnormalities, abnormal gait, dysmorphic facial features, limb anomalies, and urogenital abnormalities with hypogenitalism. A subset of more severely affected males develop congenital diaphragmatic hernia in utero, which may result in perinatal or premature death. Carrier females may have very mild skeletal or hormonal abnormalities.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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