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Mouse Anti-RNASE2 Recombinant Antibody (CBFYE-1618) (CBMAB-E2277-FY)

This product is mouse antibody that recognizes RNASE2. The antibody CBFYE-1618 can be used for immunoassay techniques such as: WB.
See all RNASE2 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYE-1618
Antibody Isotype
IgG2a
Application
WB

Basic Information

Immunogen
EDN was purified from human eosinophils
Specificity
Human
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, 50% glycerol, pH 7.2
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Ribonuclease A Family Member 2
Introduction
The protein encoded by this gene is a non-secretory ribonuclease that belongs to the pancreatic ribonuclease family, a subset of the ribonuclease A superfamily. The protein antimicrobial activity against viruses.
Entrez Gene ID
6036
UniProt ID
P10153
Alternative Names
Ribonuclease A Family Member 2; Eosinophil-Derived Neurotoxin; Ribonuclease, RNase A Family, 2 (Liver, Eosinophil-Derived Neurotoxin); Ribonuclease US; Ribonuclease 2; RNase UpI-2; EC 3.1.27.5
Function
This is a non-secretory ribonuclease. It is a pyrimidine specific nuclease with a slight preference for U. Cytotoxin and helminthotoxin. Selectively chemotactic for dendritic cells. Possesses a wide variety of biological activities.
Biological Process
Biological Process chemotaxisManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process defense response to virusManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process innate immune response in mucosaManual Assertion Based On ExperimentIBA:GO_Central
Biological Process RNA catabolic processManual Assertion Based On ExperimentTAS:ProtInc
Biological Process RNA phosphodiester bond hydrolysisManual Assertion Based On ExperimentIDA:UniProtKB
Cellular Location
Lysosome
Cytoplasmic granule
Matrix of eosinophil's large specific granule.
PTM
A particular signal processing and glycosylation pattern may differentiate the UpI2 RNase, found specifically in pregnant women urine, from other nonsecretory RNases.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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