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Mouse Anti-RNASE3 Recombinant Antibody (C6) (CBMAB-R2853-CN)

This product is a Mouse antibody that recognizes RNASE3. The antibody C6 can be used for immunoassay techniques such as: WB, ICC, IHC-P, IHC-Fr, ELISA, IP, IF, FC.
See all RNASE3 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
C6
Antibody Isotype
IgG
Application
WB, ICC, IHC-P, IHC-Fr, ELISA, IP, IF, FC

Basic Information

Immunogen
Ribonuclease A3
Specificity
Human
Antibody Isotype
IgG
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.4, 50% Glycerol
Preservative
0.02% Sodium azide
Concentration
0.5 mg/mL

Target

Full Name
Ribonuclease A Family Member 3
Introduction
The protein encoded by this gene belongs to the pancreatic ribonuclease family, a subset of the ribonuclease A superfamily. The protein exhibits antimicrobial activity against pathogenic bacteria [provided by RefSeq, Oct 2014]
Entrez Gene ID
6037
UniProt ID
P12724
Alternative Names
Ribonuclease A Family Member 3; Ribonuclease, RNase A Family, 3; Eosinophil Cationic Protein; Ribonuclease 3; RNase 3; RNS3; ECP;
Function
Cytotoxin and helminthotoxin with low-efficiency ribonuclease activity. Possesses a wide variety of biological activities. Exhibits antibacterial activity, including cytoplasmic membrane depolarization of preferentially Gram-negative, but also Gram-positive strains. Promotes E.coli outer membrane detachment, alteration of the overall cell shape and partial loss of cell content.
Biological Process
Biological Process antibacterial humoral responseManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process antimicrobial humoral immune response mediated by antimicrobial peptideManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process chemotaxisManual Assertion Based On ExperimentIBA:GO_Central
Biological Process defense response to Gram-negative bacteriumManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process defense response to Gram-positive bacteriumManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process induction of bacterial agglutinationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process innate immune responseManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process innate immune response in mucosaManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process RNA catabolic processManual Assertion Based On ExperimentTAS:ProtInc
Cellular Location
Secreted
Located in the matrix of eosinophil large specific granule, which are released following activation by an immune stimulus.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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