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Mouse Anti-RNASEH2B Recombinant Antibody (419) (CBMAB-R2866-CN)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
419
Antibody Isotype
IgG1
Application
WB

Basic Information

Immunogen
Recombinant protein encompassing a sequence within the center region of human RNaseH2B. The exact sequence is proprietary
Specificity
Human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Concentration
1.94 mg/mL

Target

Full Name
Ribonuclease H2 Subunit B
Introduction
RNase H2 is composed of a single catalytic subunit (A) and two non-catalytic subunits (B and C) and specifically degrades the RNA of RNA:DNA hybrids. The protein encoded by this gene is the non-catalytic B subunit of RNase H2, which is thought to play a role in DNA replication. Multiple transcript variants encoding different isoforms have been found for this gene. Defects in this gene are a cause of Aicardi-Goutieres syndrome type 2 (AGS2). [provided by RefSeq, Nov 2008]
Entrez Gene ID
79621
UniProt ID
Q5TBB1
Alternative Names
Ribonuclease H2 Subunit B; Deleted In Lymphocytic Leukemia 8; Aicardi-Goutieres Syndrome 2 Protein; Ribonuclease HI Subunit B; RNase H2 Subunit B; DLEU8; AGS2; Aicardi-Goutieres Syndrome 2; Ribonuclease H2, Subunit B;
Function
Non catalytic subunit of RNase H2, an endonuclease that specifically degrades the RNA of RNA:DNA hybrids. Participates in DNA replication, possibly by mediating the removal of lagging-strand Okazaki fragment RNA primers during DNA replication. Mediates the excision of single ribonucleotides from DNA:RNA duplexes.
Biological Process
Biological Process fibroblast proliferationIEA:Ensembl
Biological Process gene expressionIEA:Ensembl
Biological Process in utero embryonic developmentIEA:Ensembl
Biological Process mismatch repair1 PublicationIC:ComplexPortal
Biological Process negative regulation of gene expressionIEA:Ensembl
Biological Process positive regulation of fibroblast proliferationIEA:Ensembl
Biological Process regulation of DNA damage checkpointIEA:Ensembl
Biological Process regulation of G2/M transition of mitotic cell cycleIEA:Ensembl
Biological Process ribonucleotide metabolic processManual Assertion Based On ExperimentIBA:GO_Central
Biological Process RNA catabolic processManual Assertion Based On ExperimentIDA:UniProtKB
Cellular Location
Nucleus
Involvement in disease
Aicardi-Goutieres syndrome 2 (AGS2):
A form of Aicardi-Goutieres syndrome, a genetically heterogeneous disease characterized by cerebral atrophy, leukoencephalopathy, intracranial calcifications, chronic cerebrospinal fluid (CSF) lymphocytosis, increased CSF alpha-interferon, and negative serologic investigations for common prenatal infection. Clinical features as thrombocytopenia, hepatosplenomegaly and elevated hepatic transaminases along with intermittent fever may erroneously suggest an infective process. Severe neurological dysfunctions manifest in infancy as progressive microcephaly, spasticity, dystonic posturing and profound psychomotor retardation. Death often occurs in early childhood.
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For research use only. Not intended for any clinical use.

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