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Rabbit Anti-RNASEL Recombinant Antibody (D4B4J) (CBMAB-CP2286-LY)

The product is antibody recognizes RNASEL. The antibody D4B4J immunoassay techniques such as: WB.
See all RNASEL antibodies

Summary

Host Animal
Rabbit
Specificity
Human, Mouse
Clone
D4B4J
Antibody Isotype
IgG
Application
WB

Basic Information

Immunogen
Monoclonal antibody is produced by immunizing animals with a synthetic peptide corresponding to residues surrounding Pro717 of human RNase L protein.
Specificity
Human, Mouse
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
Ribonuclease L
Introduction
This gene encodes a component of the interferon-regulated 2-5A system that functions in the antiviral and antiproliferative roles of interferons. Mutations in this gene have been associated with predisposition to prostate cancer and this gene is a candidate for the hereditary prostate cancer 1 (HPC1) allele. [provided by RefSeq, Jul 2008]
Entrez Gene ID
Human6041
Mouse24014
UniProt ID
HumanQ05823
MouseQ05921
Alternative Names
Ribonuclease L; 2-5A-Dependent RNase; Ribonuclease 4; RNase L; RNS4; Ribonuclease L (2;5-Oligoisoadenylate Synthetase-Dependent); 2;5-Oligoisoadenylate Synthetase-Dependent;
Function
Endoribonuclease that functions in the interferon (IFN) antiviral response. In INF treated and virus infected cells, RNASEL probably mediates its antiviral effects through a combination of direct cleavage of single-stranded viral RNAs, inhibition of protein synthesis through the degradation of rRNA, induction of apoptosis, and induction of other antiviral genes. RNASEL mediated apoptosis is the result of a JNK-dependent stress-response pathway leading to cytochrome c release from mitochondria and caspase-dependent apoptosis. Therefore, activation of RNASEL could lead to elimination of virus infected cells under some circumstances. In the crosstalk between autophagy and apoptosis proposed to induce autophagy as an early stress response to small double-stranded RNA and at later stages of prolonged stress to activate caspase-dependent proteolytic cleavage of BECN1 to terminate autophagy and promote apoptosis (PubMed:26263979).
Might play a central role in the regulation of mRNA turnover (PubMed:11585831).
Cleaves 3' of UpNp dimers, with preference for UU and UA sequences, to sets of discrete products ranging from between 4 and 22 nucleotides in length.
Biological Process
Biological Process defense response to virusManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process fat cell differentiationIEA:Ensembl
Biological Process mRNA processingIEA:InterPro
Biological Process negative regulation of viral genome replicationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process positive regulation of glucose importIEA:Ensembl
Biological Process positive regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process protein phosphorylation1 PublicationNAS:UniProtKB
Biological Process regulation of mRNA stabilityIEA:Ensembl
Biological Process RNA processingManual Assertion Based On ExperimentIBA:GO_Central
Biological Process rRNA processingIEA:Ensembl
Cellular Location
Cytoplasm
Mitochondrion
Involvement in disease
Prostate cancer, hereditary, 1 (HPC1):
A condition associated with familial predisposition to cancer of the prostate. Most prostate cancers are adenocarcinomas that develop in the acini of the prostatic ducts. Other rare histopathologic types of prostate cancer that occur in approximately 5% of patients include small cell carcinoma, mucinous carcinoma, prostatic ductal carcinoma, transitional cell carcinoma, squamous cell carcinoma, basal cell carcinoma, adenoid cystic carcinoma (basaloid), signet-ring cell carcinoma and neuroendocrine carcinoma.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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