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Mouse Anti-RNF11 Recombinant Antibody (CBCNR-565) (CBMAB-R2891-CN)

This product is a Mouse antibody that recognizes RNF11. The antibody CBCNR-565 can be used for immunoassay techniques such as: WB, IHC-P, FC.
See all RNF11 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBCNR-565
Antibody Isotype
IgG2a
Application
WB, IHC-P, FC

Basic Information

Specificity
Human
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Concentration
1 mg/mL

Target

Full Name
ring finger protein 11
Introduction
The protein encoded by this gene contains a RING-H2 finger motif, which is known to be important for protein-protein interactions. The expression of this gene has been shown to be induced by mutant RET proteins (MEN2A/MEN2B). The germline mutations in RET gene are known to be responsible for the development of multiple endocrine neoplasia (MEN). [provided by RefSeq, Jul 2008]
Entrez Gene ID
UniProt ID
Alternative Names
Ring Finger Protein 11; CGI-123; SID1669;
Function
Essential component of a ubiquitin-editing protein complex, comprising also TNFAIP3, ITCH and TAX1BP1, that ensures the transient nature of inflammatory signaling pathways. Promotes the association of TNFAIP3 to RIPK1 after TNF stimulation. TNFAIP3 deubiquitinates 'Lys-63' polyubiquitin chains on RIPK1 and catalyzes the formation of 'Lys-48'-polyubiquitin chains. This leads to RIPK1 proteasomal degradation and consequently termination of the TNF- or LPS-mediated activation of NF-kappa-B. Recruits STAMBP to the E3 ubiquitin-ligase SMURF2 for ubiquitination, leading to its degradation by the 26S proteasome.
Biological Process
Biological Process protein autoubiquitinationManual Assertion Based On ExperimentIDA:FlyBase
Biological Process ubiquitin-dependent protein catabolic processManual Assertion Based On ExperimentIDA:UniProtKB
Cellular Location
Early endosome
Recycling endosome
Cytoplasm
Nucleus
Predominantly cytoplasmic, when unphosphorylated, and nuclear, when phosphorylated by PKB/AKT1.
PTM
Ubiquitinated in the presence of ITCH, or SMURF2, and UBE2D1, as well as WWP1.
Phosphorylation by PKB/AKT1 may accelerate degradation by the proteasome.
Acylation at both Gly-2 and Cys-4 is required for proper localization to the endosomes.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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