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Mouse Anti-RNF113A Recombinant Antibody (3F3) (CBMAB-R2894-CN)

This product is a Mouse antibody that recognizes RNF113A. The antibody 3F3 can be used for immunoassay techniques such as: ELISA, WB.
See all RNF113A antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
3F3
Antibody Isotype
IgG2a, κ
Application
ELISA, WB

Basic Information

Immunogen
Full-length recombinant corresponding to aa. 1-344 from human RNF113A (H00832) with GST tag
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.2

Target

Full Name
ring finger protein 113A
Introduction
This intronless gene encodes a protein which contains a C3H1-type zinc finger domain and a C3HC4 Ring-type (Really Interesting New Gene-type) zinc finger domain. The Ring-type zinc finger domain is identified in various tumor suppressors, DNA repair genes and cytokine receptor-associated molecules, and is probably involved in mediating protein-protein interactions. [provided by RefSeq, May 2010]
Entrez Gene ID
7737
UniProt ID
O15541
Alternative Names
Ring Finger Protein 113A; Zinc Finger Protein 183 (RING Finger, C3HC4 Type); ZNF183; RNF113; Zinc Finger Protein 183; Cwc24; TTD5;
Function
Required for pre-mRNA splicing as component of the spliceosome (PubMed:29361316, PubMed:29360106).
E3 ubiquitin-protein ligase that catalyzes the transfer of ubiquitin onto target proteins (PubMed:28978524, PubMed:29144457).
Catalyzes polyubiquitination of SNRNP200/BRR2 with non-canonical 'Lys-63'-linked polyubiquitin chains (PubMed:29144457).
Plays a role in DNA repair via its role in the synthesis of 'Lys-63'-linked polyubiquitin chains that recruit ALKBH3 and the ASCC complex to sites of DNA damage by alkylating agents (PubMed:29144457).
Ubiquitinates CXCR4, leading to its degradation, and thereby contributes to the termination of CXCR4 signaling (PubMed:28978524).
Biological Process
Biological Process DNA repairIEA:UniProtKB-KW
Biological Process isopeptide cross-linking via N6-glycyl-L-lysineManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process mRNA splicing, via spliceosomeManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process negative regulation of chemokine-mediated signaling pathwayManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process protein ubiquitinationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process snoRNA splicingManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Nucleus
Nucleus speckle
Colocalizes with ASCC2 in nuclear foci after DNA damage by alkylating agents. In the absence of DNA damage, colocalizes with the spliceosome components SNRNP200/BRR2 and PRPF8 in nuclear speckles.
Involvement in disease
Trichothiodystrophy 5, non-photosensitive (TTD5):
An X-linked form of trichothiodystrophy, a disease characterized by sulfur-deficient brittle hair and multisystem variable abnormalities. The spectrum of clinical features varies from mild disease with only hair involvement to severe disease with cutaneous, neurologic and profound developmental defects. Ichthyosis, intellectual and developmental disabilities, decreased fertility, abnormal characteristics at birth, ocular abnormalities, short stature, and infections are common manifestations. There are both photosensitive and non-photosensitive forms of the disorder. TTD5 features include microcephaly, profound intellectual disability, sparse brittle hair, aged appearance, short stature, facial dysmorphism, seizures, an immunoglobulin deficiency, multiple endocrine abnormalities, cerebellar hypoplasia and partial absence of the corpus callosum, in the absence of cellular photosensitivity and ichthyosis.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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