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Rabbit Anti-RNF115 Recombinant Antibody (CBWJZ-196) (CBMAB-Z0523-WJ)


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Summary

Host Animal
Rabbit
Specificity
Mouse, Rat, Human
Clone
CBWJZ-196
Antibody Isotype
IgG
Application
WB

Basic Information

Specificity
Mouse, Rat, Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Concentration
2.253 mg/mL

Target

Full Name
Ring Finger Protein 115
Introduction
RNF115 (Ring Finger Protein 115) is a Protein Coding gene. Among its related pathways are Innate Immune System and Class I MHC mediated antigen processing and presentation. Gene Ontology (GO) annotations related to this gene include ligase activity and ubiquitin protein ligase activity. An important paralog of this gene is RNF126.
Entrez Gene ID
Human27246
Mouse67845
Rat362002
UniProt ID
HumanQ9Y4L5
MouseQ9D0C1
RatD3ZB96
Alternative Names
BCA2; ZNF364
Function
E3 ubiquitin-protein ligase that mediates E2-dependent, 'Lys-48'- and/or 'Lys-63'-linked polyubiquitination of substrates and may play a role in diverse biological processes. Through their polyubiquitination, may play a role in the endosomal trafficking and degradation of membrane receptors including EGFR, FLT3, MET and CXCR4.
Biological Process
Biological Process negative regulation of epidermal growth factor receptor signaling pathwayManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process protein autoubiquitinationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process protein K48-linked ubiquitinationISS:UniProtKB
Biological Process protein K63-linked ubiquitinationISS:UniProtKB
Biological Process ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathwayManual Assertion Based On ExperimentIMP:UniProtKB
Cellular Location
Cytoplasm, cytosol
The GTP-bound form of RAB7A recruits RNF115 from the cytosol onto late endosomes/lysosomes.
PTM
RING-type zinc finger-dependent and E2-dependent autoubiquitination.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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