Rabbit Anti-RNF115 Recombinant Antibody (CBWJZ-196) (CBMAB-Z0523-WJ)

Name: Rabbit Anti-RNF115 Recombinant Antibody (CBWJZ-196)
SKU: CBMAB-Z0523-WJ
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Rabbit

Clone

CBWJZ-196

Application

Specificity

Mouse, Rat, Human

Antibody Isotype

IgG

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Concentration

2.253 mg/mL

More Infomation

Target

Full Name

Ring Finger Protein 115

Introduction

RNF115 (Ring Finger Protein 115) is a Protein Coding gene. Among its related pathways are Innate Immune System and Class I MHC mediated antigen processing and presentation. Gene Ontology (GO) annotations related to this gene include ligase activity and ubiquitin protein ligase activity. An important paralog of this gene is RNF126.

Entrez Gene ID

Human	27246
Mouse	67845
Rat	362002

UniProt ID

Human	Q9Y4L5
Mouse	Q9D0C1
Rat	D3ZB96

Alternative Names

BCA2; ZNF364

Function

E3 ubiquitin-protein ligase that mediates E2-dependent, 'Lys-48'- and/or 'Lys-63'-linked polyubiquitination of substrates and may play a role in diverse biological processes. Through their polyubiquitination, may play a role in the endosomal trafficking and degradation of membrane receptors including EGFR, FLT3, MET and CXCR4.

Biological Process

Biological Process negative regulation of epidermal growth factor receptor signaling pathwayManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process protein autoubiquitinationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process protein K48-linked ubiquitinationISS:UniProtKB
Biological Process protein K63-linked ubiquitinationISS:UniProtKB
Biological Process ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathwayManual Assertion Based On ExperimentIMP:UniProtKB

Cellular Location

Cytoplasm, cytosol
The GTP-bound form of RAB7A recruits RNF115 from the cytosol onto late endosomes/lysosomes.

PTM

RING-type zinc finger-dependent and E2-dependent autoubiquitination.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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