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Mouse Anti-RNF123 Recombinant Antibody (3F8) (CBMAB-R2909-CN)

This product is a Mouse antibody that recognizes RNF123. The antibody 3F8 can be used for immunoassay techniques such as: ELISA, WB.
See all RNF123 antibodies
Published Data
Fig. 1 Immunoblot analysis of cleavage products of IPSes.
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Summary

Host Animal
Mouse
Specificity
Human
Clone
3F8
Antibody Isotype
IgG1, κ
Application
ELISA, WB

Basic Information

Immunogen
Partial recombinant corresponding to aa. 1216-1315 from human RNF123 (NP_071347) with GST tag
Specificity
Human
Antibody Isotype
IgG1, κ
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.2

Target

Full Name
ring finger protein 123
Introduction
The protein encoded by this gene contains a C-terminal RING finger domain, a motif present in a variety of functionally distinct proteins and known to be involved in protein-protein and protein-DNA interactions, and an N-terminal SPRY domain. This protein displays E3 ubiquitin ligase activity toward the cyclin-dependent kinase inhibitor 1B which is also known as p27 or KIP1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2016]
Entrez Gene ID
63891
UniProt ID
Q5XPI4
Alternative Names
Ring Finger Protein 123; Kip1 Ubiquitination-Promoting Complex Subunit 1; Kip1 Ubiquitination-Promoting Complex Protein 1; RING-Type E3 Ubiquitin Transferase RNF123; RING Finger Protein 123; KPC1; E3 Ubiquitin-Protein Ligase RNF123; EC 2.3.2.27; FP1477;
Function
Catalytic subunit of the KPC complex that acts as E3 ubiquitin-protein ligase. Promotes the ubiquitination and proteasome-mediated degradation of CDKN1B which is the cyclin-dependent kinase inhibitor at the G0-G1 transition of the cell cycle (PubMed:15531880, PubMed:16227581).
Functions also as an inhibitor of innate antiviral signaling mediated by DDX58 and IFIH1 independently of its E3 ligase activity (PubMed:27312109).
Interacts with the N-terminal CARD domains of DDX58 and IFIH1 and competes with the downstream adapter MAVS (PubMed:27312109).
Biological Process
Proteolysis involved in protein catabolic process
Cellular Location
Cytoplasm
PTM
Ubiquitinated, leading to its degradation. Deubiquitinated by USP19, thereby stimulating CDKN1B ubiquitin-dependent degradation.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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