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Mouse Anti-RNF13 Recombinant Antibody (CBCNR-574) (CBMAB-R2918-CN)

This product is a Mouse antibody that recognizes RNF13. The antibody CBCNR-574 can be used for immunoassay techniques such as: ELISA, WB.
See all RNF13 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBCNR-574
Antibody Isotype
IgG2a, κ
Application
ELISA, WB

Basic Information

Immunogen
RNF13 (NP_009213, aa. 51-150) partial recombinant protein with GST tag
Specificity
Human
Antibody Isotype
IgG2a, κ
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
1× PBS, pH 7.2

Target

Full Name
ring finger protein 13
Introduction
The protein encoded by this gene contains a RING zinc finger, a motif known to be involved in protein-protein interactions. The specific function of this gene has not yet been determined. Alternatively spliced transcript variants that encode the same protein have been reported. A pseudogene, which is also located on chromosome 3, has been defined for this gene. [provided by RefSeq, Jul 2008]
Entrez Gene ID
11342
UniProt ID
O43567
Alternative Names
Ring Finger Protein 13; RING-Type E3 Ubiquitin Transferase RNF13; RING Finger Protein 13; RZF; E3 Ubiquitin-Protein Ligase RNF13; RING Zinc Finger Protein; EC 2.3.2.27;
Function
E3 ubiquitin-protein ligase that regulates cell proliferation (PubMed:18794910, PubMed:23378536, PubMed:30595371).
Involved in apoptosis regulation (PubMed:23378536, PubMed:30595371).
Mediates ER stress-induced activation of JNK signaling pathway and apoptosis by promoting ERN1 activation and splicing of XBP1 mRNA (PubMed:23378536, PubMed:30595371).
Also involved in protein trafficking and localization (PubMed:24387786).
Biological Process
Biological Process organelle localizationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process positive regulation of stress-activated protein kinase signaling cascadeManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process protein autoubiquitinationISS:UniProtKB
Biological Process ubiquitin-dependent protein catabolic processManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Endoplasmic reticulum membrane
Late endosome membrane
Lysosome membrane
Nucleus inner membrane
Under certain conditions, relocalizes to recycling endosomes and to the inner nuclear membrane.
Involvement in disease
Developmental and epileptic encephalopathy 73 (DEE73):
A form of epileptic encephalopathy, a heterogeneous group of severe early-onset epilepsies characterized by refractory seizures, neurodevelopmental impairment, and poor prognosis. Development is normal prior to seizure onset, after which cognitive and motor delays become apparent. DEE73 is an autosomal dominant form with onset at birth.
Topology
Lumenal: 35-182
Helical: 183-203
Cytoplasmic: 204-381
PTM
Autoubiquitinated.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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