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Mouse Anti-RNF138 Recombinant Antibody (3G2) (CBMAB-R2921-CN)

This product is a Mouse antibody that recognizes RNF138. The antibody 3G2 can be used for immunoassay techniques such as: ELISA, WB.
See all RNF138 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
3G2
Antibody Isotype
IgM, κ
Application
ELISA, WB

Basic Information

Immunogen
Partial recombinant corresponding to aa. 51-151 from human RNF138 with GST tag
Specificity
Human
Antibody Isotype
IgM, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
Ascites

Target

Full Name
Ring Finger Protein 138
Introduction
The protein encoded by this gene contains a RING finger, a motif present in a variety of functionally distinct proteins and known to be involved in protein-DNA and protein-protein interactions. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]
Entrez Gene ID
51444
UniProt ID
Q8WVD3
Alternative Names
Ring Finger Protein 138; Ring Finger Protein 138, E3 Ubiquitin Protein Ligase; Nemo-Like Kinase Associated Ring Finger Protein; Nemo-Like Kinase-Associated RING Finger Protein; RING-Type E3 Ubiquitin Transferase RNF138; NLK-Associated RING Finger Protein; RING Finger Protein 138; HNARF;
Function
E3 ubiquitin-protein ligase involved in DNA damage response by promoting DNA resection and homologous recombination (PubMed:26502055, PubMed:26502057).
Recruited to sites of double-strand breaks following DNA damage and specifically promotes double-strand break repair via homologous recombination (PubMed:26502055, PubMed:26502057).
Two different, non-exclusive, mechanisms have been proposed. According to a report, regulates the choice of double-strand break repair by favoring homologous recombination over non-homologous end joining (NHEJ): acts by mediating ubiquitination of XRCC5/Ku80, leading to remove the Ku complex from DNA breaks, thereby promoting homologous recombination (PubMed:26502055).
According to another report, cooperates with UBE2Ds E2 ubiquitin ligases (UBE2D1, UBE2D2, UBE2D3 or UBE2D4) to promote homologous recombination by mediating ubiquitination of RBBP8/CtIP (PubMed:26502057).
Together with NLK, involved in the ubiquitination and degradation of TCF/LEF (PubMed:16714285).
Also exhibits auto-ubiquitination activity in combination with UBE2K (PubMed:16714285).
May act as a negative regulator in the Wnt/beta-catenin-mediated signaling pathway (PubMed:16714285).
Biological Process
Biological Process DNA double-strand break processing involved in repair via single-strand annealingManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process double-strand break repair via homologous recombinationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process protein ubiquitinationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process Wnt signaling pathwayIEA:UniProtKB-KW
Cellular Location
Chromosome
Recruited at DNA damage sites (PubMed:26502055).
Localizes to sites of double-strand break: localization to double-strand break sites is mediated by the zinc fingers (PubMed:26502055, PubMed:26502057).
PTM
Auto-ubiquitinated.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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