Mouse Anti-RNF138 Recombinant Antibody (3G2) (CBMAB-R2921-CN)

Name: Mouse Anti-RNF138 Recombinant Antibody (3G2)
SKU: CBMAB-R2921-CN
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

3G2

Application

ELISA, WB

Immunogen

Partial recombinant corresponding to aa. 51-151 from human RNF138 with GST tag

Specificity

Human

Antibody Isotype

IgM, κ

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

Ascites

More Infomation

Target

Full Name

Ring Finger Protein 138

Introduction

The protein encoded by this gene contains a RING finger, a motif present in a variety of functionally distinct proteins and known to be involved in protein-DNA and protein-protein interactions. Alternatively spliced transcript variants encoding distinct isoforms have been observed. [provided by RefSeq, Jul 2008]

Entrez Gene ID

51444

UniProt ID

Q8WVD3

Alternative Names

Ring Finger Protein 138; Ring Finger Protein 138, E3 Ubiquitin Protein Ligase; Nemo-Like Kinase Associated Ring Finger Protein; Nemo-Like Kinase-Associated RING Finger Protein; RING-Type E3 Ubiquitin Transferase RNF138; NLK-Associated RING Finger Protein; RING Finger Protein 138; HNARF;

Function

E3 ubiquitin-protein ligase involved in DNA damage response by promoting DNA resection and homologous recombination (PubMed:26502055, PubMed:26502057).
Recruited to sites of double-strand breaks following DNA damage and specifically promotes double-strand break repair via homologous recombination (PubMed:26502055, PubMed:26502057).
Two different, non-exclusive, mechanisms have been proposed. According to a report, regulates the choice of double-strand break repair by favoring homologous recombination over non-homologous end joining (NHEJ): acts by mediating ubiquitination of XRCC5/Ku80, leading to remove the Ku complex from DNA breaks, thereby promoting homologous recombination (PubMed:26502055).
According to another report, cooperates with UBE2Ds E2 ubiquitin ligases (UBE2D1, UBE2D2, UBE2D3 or UBE2D4) to promote homologous recombination by mediating ubiquitination of RBBP8/CtIP (PubMed:26502057).
Together with NLK, involved in the ubiquitination and degradation of TCF/LEF (PubMed:16714285).
Also exhibits auto-ubiquitination activity in combination with UBE2K (PubMed:16714285).
May act as a negative regulator in the Wnt/beta-catenin-mediated signaling pathway (PubMed:16714285).

Biological Process

Biological Process DNA double-strand break processing involved in repair via single-strand annealingManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process double-strand break repair via homologous recombinationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process protein ubiquitinationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process Wnt signaling pathwayIEA:UniProtKB-KW

Cellular Location

Chromosome
Recruited at DNA damage sites (PubMed:26502055).
Localizes to sites of double-strand break: localization to double-strand break sites is mediated by the zinc fingers (PubMed:26502055, PubMed:26502057).

PTM

Auto-ubiquitinated.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Related Products

Mouse Anti-RNF138 Recombinant Antibody (CBCNR-576) (CAT#: CBMAB-R2922-CN)

Isotype control

For research use only. Not intended for any clinical use.

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We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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