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Mouse Anti-RNF186 Recombinant Antibody (CBCNR-599) (CBMAB-R2978-CN)

This product is a Mouse antibody that recognizes RNF186. The antibody CBCNR-599 can be used for immunoassay techniques such as: ELISA, WB.
See all RNF186 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBCNR-599
Antibody Isotype
IgG1, κ
Application
ELISA, WB

Basic Information

Immunogen
RNF186 (NP_061935, aa. 75-150) partial recombinant protein with GST tag
Specificity
Human
Antibody Isotype
IgG1, κ
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
1× PBS, pH 7.2

Target

Full Name
ring finger protein 186
Introduction
RNF186 (Ring Finger Protein 186) is a Protein Coding gene. Diseases associated with RNF186 include Hartnup Disorder.
Entrez Gene ID
54546
UniProt ID
Q9NXI6
Alternative Names
Ring Finger Protein 186; Hypothetical Protein FLJ20225;
Function
E3 ubiquitin protein ligase that is part of an apoptotic signaling pathway activated by endoplasmic reticulum stress (PubMed:23896122).
Stimulates the expression of proteins specific of the unfolded protein response (UPR), ubiquitinates BNIP1 and regulates its localization to the mitochondrion and induces calcium release from the endoplasmic reticulum that ultimately leads to cell apoptosis (PubMed:23896122).
Plays a role in the maintenance of intestinal homeostasis and clearance of enteric pathogens. Upon NOD2 stimulation, ubiquitinates the ER stress sensor activating transcription factor 6/ATF6 and promotes the unfolded protein response UPR (PubMed:34623328).
Participates in basal level of autophagy maintenance by regulating the ubiquitination of EPHB2 and EPHB3. Upon stimulation by ligand EFNB1, ubiquitinates EPHB2 and further recruits MAP1LC3B for autophagy induction (PubMed:33280498).
Controls nutrient sensing by ubiquitinating Sestrin-2/SESN2, which is an intracellular sensor of cytosolic leucine and inhibitor of mTORC1 activity (PubMed:31586034).
Biological Process
Biological Process intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stressManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process proteasome-mediated ubiquitin-dependent protein catabolic processManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process protein autoubiquitinationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process protein K29-linked ubiquitinationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process protein K63-linked ubiquitinationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process protein localization to mitochondrionManual Assertion Based On ExperimentIMP:UniProtKB
Cellular Location
Endoplasmic reticulum membrane
PTM
Polyubiquitinated. 'Lys-29'-linked autoubiquitination leads to proteasomal degradation.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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