Mouse Anti-RNF187 Recombinant Antibody (5H10) (CBMAB-R2980-CN)

Name: Mouse Anti-RNF187 Recombinant Antibody (5H10)
SKU: CBMAB-R2980-CN
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

5H10

Application

WB, IP, ELISA

Specificity

Mouse, Rat, Human

Antibody Isotype

IgG1

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Concentration

1 mg/mL

More Infomation

Target

Full Name

Ring Finger Protein 187

Introduction

RNF187 (Ring Finger Protein 187) is a Protein Coding gene. Gene Ontology (GO) annotations related to this gene include ligase activity and ubiquitin-protein transferase activity.

Entrez Gene ID

Human	149603
Mouse	108660
Rat	360533

UniProt ID

Human	Q5TA31
Mouse	Q8BFX1
Rat	D3Z8N2

Alternative Names

Ring Finger Protein 187; RING-Type E3 Ubiquitin Transferase RNF187; Ring Domain AP-1 Co-Activator 1; RING Domain AP1 Coactivator 1; RING Finger Protein 187; RACO-1;

Function

E3 ubiquitin-protein ligase that acts as a coactivator of JUN-mediated gene activation in response to growth factor signaling via the MAP3K1 pathway, independently from MAPK8.

Biological Process

Biological Process innate immune responseManual Assertion Based On ExperimentIBA:GO_Central
Biological Process positive regulation of cell population proliferationISS:UniProtKB
Biological Process positive regulation of transcription, DNA-templatedManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process proteasome-mediated ubiquitin-dependent protein catabolic processManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process protein autoubiquitinationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process protein K48-linked ubiquitinationManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process protein ubiquitinationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process regulation of gene expressionManual Assertion Based On ExperimentIBA:GO_Central

Cellular Location

Cytoplasm
Nucleus
Predominantly located in the cytoplasm. Shuttles between the cytoplasm and the nucleus.

PTM

Ubiquitinated; undergoes 'Lys-48'-linked autoubiquitination in the absence of growth factors and MAP3K1-induced 'Lys-63'-linked polyubiquitination (PubMed:20852630).
'Lys-48'-autoubiquitination leads to degradation by the proteasome, while MAP3K1-induced 'Lys-63'-linked polyubiquitination results in the stabilization of the protein (PubMed:20852630).
'Lys-48'- and 'Lys-63'-linked polyubiquitinations occur most probably on the same 3 C-terminal lysine residues (Lys-195, Lys-223 and Lys-224) and are thus mutually exclusive (PubMed:20852630).
Other sites of ubiquitination are not excluded (PubMed:20852630).
'Lys-63'-linked polyubiquitination by TRIM7 in response to growth factor signaling via the MEK/ERK pathway enhances protein stability (PubMed:25851810).
Arginine methylation by PRMT1 stabilizes RNF187 by facilitating K63-linked ubiquitin chain formation, and enables dimerization, c-Jun interaction and subsequent AP1 target gene expression.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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