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Mouse Anti-RNF217 Recombinant Antibody (CBYY-I0882) (CBMAB-I2050-YY)

This product is Mouse antibody that recognizes RNF217. The antibody CBYY-I0882 can be used for immunoassay techniques such as: WB, ELISA, IF
See all RNF217 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYY-I0882
Antibody Isotype
IgG2a, κ
Application
WB, ELISA, IF

Basic Information

Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Ring Finger Protein 217
Introduction
This protein encoded by this gene is a member of the RING1-IBR-RING24 (RBR) ubiquitin protein ligase family, and it belongs to a subfamily of these proteins that contain a transmembrane domain. This protein can interact with the HAX1 anti-apoptotic protein via its C-terminal RING finger motif, which suggests a role in apoptosis signaling. It is thought that deregulation of this gene can be a mechanism in leukemogenesis. Mutations in the region encoding the protein GXXXG motif, which appears to be necessary for protein self-association, have been found in human cancers. Alternative splicing of this gene results in multiple transcript variants.
Entrez Gene ID
3620
UniProt ID
P14902
Alternative Names
Ring Finger Protein 217; IBR Domain Containing 1; RING Finger Protein 217; C6orf172; IBRDC1; Probable E3 Ubiquitin-Protein Ligase RNF217; Chromosome 6 Open Reading Frame 172;
Function
E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. Mediates the degradation of the iron exporter ferroportin/SLC40A1 and thus regulates iron homeostasis.
Biological Process
Biological Process positive regulation of proteasomal ubiquitin-dependent protein catabolic processManual Assertion Based On ExperimentIBA:GO_Central
Biological Process protein polyubiquitinationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process ubiquitin-dependent protein catabolic processISS:UniProtKB
Cellular Location
Membrane
Cytoplasm
Topology
Helical: 503-523
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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