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Mouse Anti-RNF26 Recombinant Antibody (5B9) (CBMAB-R3027-CN)

This product is a Mouse antibody that recognizes RNF26. The antibody 5B9 can be used for immunoassay techniques such as: ELISA, WB.
See all RNF26 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
5B9
Antibody Isotype
IgG3, κ
Application
ELISA, WB

Basic Information

Immunogen
Partial recombinant corresponding to aa. 344-434 from human RNF26 (NP_114404) with GST tag
Specificity
Human
Antibody Isotype
IgG3, κ
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.2

Target

Full Name
ring finger protein 26
Introduction
The protein encoded by this intronless gene contains a C3HC5 type of RING finger, a motif known to be involved in protein-DNA and protein-protein interactions. The expression of this gene was found to be upregulated in cancer cell lines derived from different types of cancer. [provided by RefSeq, Jul 2008]
Entrez Gene ID
79102
UniProt ID
Q9BY78
Alternative Names
Ring Finger Protein 26; RING Finger Protein 26; Ring Finger Protein With Leucine Zipper; EC 2.3.2.27;
Function
E3 ubiquitin-protein ligase that plays a key role in endosome organization by retaining vesicles in the perinuclear cloud (PubMed:27368102).
Acts as a platform for perinuclear positioning of the endosomal system by mediating ubiquitination of SQSTM1 through interaction with the ubiquitin conjugating enzyme UBE2J1 (PubMed:27368102, PubMed:33472082).
Ubiquitinated SQSTM1 attracts specific vesicle-associated adapters, forming a molecular bridge that restrains cognate vesicles in the perinuclear region and organizes the endosomal pathway for efficient cargo transport (PubMed:27368102, PubMed:33472082).
Also acts as a regulator of type I interferon production in response to viral infection by mediating the formation of 'Lys-11'-linked polyubiquitin chains on TMEM173/STING, leading to stabilize TMEM173/STING (PubMed:25254379, PubMed:32614325).
Also required to limit type I interferon response by promoting autophagic degradation of IRF3 (PubMed:25254379).
Biological Process
Biological Process endosome organizationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process negative regulation of defense response to virusManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process protein K11-linked ubiquitinationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process protein localization to perinuclear region of cytoplasmManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process protein ubiquitinationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process regulation of type I interferon productionManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process ubiquitin-dependent protein catabolic processManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Endoplasmic reticulum membrane
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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