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Mouse Anti-RNFT1 Recombinant Antibody (CBYJL-2335) (CBMAB-L2637-YJ)

Provided herein is a Mouse monoclonal antibody, which binds to Ring Finger Protein Transmembrane 1 (RNFT1). The antibody can be used for immunoassay techniques, such as WB.
See all RNFT1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBYJL-2335
Antibody Isotype
IgG2a, κ
Application
WB

Basic Information

Immunogen
LOC51136 (NP_057209, 1 a.a. ~ 101 a.a) partial recombinant protein with GST tag. MW of the GST tag alone is 26 K.
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
PBS, pH 7.4
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
aa 1-101

Target

Full Name
Ring Finger Protein, Transmembrane 1
Introduction
Diseases associated with RNFT1 include Spermatogenic Failure, X-Linked, 1. An important paralog of this gene is RNFT2.
Entrez Gene ID
51136
UniProt ID
Q5M7Z0
Alternative Names
Ring Finger Protein, Transmembrane 1; RING Finger And Transmembrane Domain-Containing Protein 1; E3 Ubiquitin-Protein Ligase RNFT1; Protein PTD016; EC 2.3.2.27; PTD016
Function
E3 ubiquitin-protein ligase that acts in the endoplasmic reticulum (ER)-associated degradation (ERAD) pathway, which targets misfolded proteins that accumulate in the endoplasmic reticulum (ER) for ubiquitination and subsequent proteasome-mediated degradation. Protects cells from ER stress-induced apoptosis.
Biological Process
Biological Process positive regulation of ERAD pathwayManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process protein autoubiquitinationManual Assertion Based On ExperimentIDA:UniProtKB
Cellular Location
Endoplasmic reticulum membrane
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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