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Mouse Anti-ROR1 Monoclonal Antibody (2H6) (CBMAB-1449-YC)

Provided herein is a mouse monoclonal antibody against human ROR1. The antibody, clone 2H6, can be used for immunoassay techniques, such as ELISA, FC, ICC, IF and WB.
See all ROR1 antibodies

Summary

Host Animal
Mouse
Specificity
human
Clone
2H6
Antibody Isotype
IgG1
Application
ELISA, FC, ICC, IF, WB

Basic Information

Immunogen
Recombinant fragment, corresponding to extracellular aA 30-406 of Human ROR1 fused with hIgGFc tag, expressed in HEK293 cells.
Specificity
human
Antibody Isotype
IgG1
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Receptor Tyrosine Kinase Like Orphan Receptor 1
Introduction
ROR1 is a receptor tyrosine kinase-like orphan receptor that modulates neurite growth in the central nervous system which is a glycosylated type I membrane protein that belongs to the ROR subfamily of cell surface receptors. It is a pseudokinase that lacks catalytic activity and may interact with the non-canonical Wnt signalling pathway. This gene is highly expressed during early embryonic development but expressed at very low levels in adult tissues. Increased expression of this gene is associated with B-cell chronic lymphocytic leukaemia.
Entrez Gene ID
4919
UniProt ID
Q01973
Alternative Names
NTRKR1; dJ537F10.1
Function
Has very low kinase activity in vitro and is unlikely to function as a tyrosine kinase in vivo (PubMed:25029443).
Receptor for ligand WNT5A which activate downstream NFkB signaling pathway and may result in the inhibition of WNT3A-mediated signaling (PubMed:25029443, PubMed:27162350).
In inner ear, crucial for spiral ganglion neurons to innervate auditory hair cells (PubMed:27162350).
Biological Process
Biological Process astrocyte developmentIEA:Ensembl
Biological Process inner ear developmentISS:UniProtKB
Biological Process positive regulation of I-kappaB kinase/NF-kappaB signalingManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process positive regulation of kinase activityManual Assertion Based On ExperimentIBA:GO_Central
Biological Process positive regulation of neuron projection developmentManual Assertion Based On ExperimentIBA:GO_Central
Biological Process positive regulation of NF-kappaB transcription factor activityManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process positive regulation of phosphatidylinositol 3-kinase signalingManual Assertion Based On ExperimentIBA:GO_Central
Biological Process sensory perception of soundManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process transmembrane receptor protein tyrosine kinase signaling pathwayManual Assertion Based On ExperimentTAS:ProtInc
Cellular Location
Membrane
Cell projection, axon
Involvement in disease
Deafness, autosomal recessive, 108 (DFNB108):
A form of non-syndromic sensorineural hearing loss. Sensorineural deafness results from damage to the neural receptors of the inner ear, the nerve pathways to the brain, or the area of the brain that receives sound information.
Topology
Extracellular: 30-406
Helical: 407-427
Cytoplasmic: 428-937
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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