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Mouse Anti-RPL21 Recombinant Antibody (2D8) (CBMAB-R3371-CN)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
2D8
Antibody Isotype
IgG2b, κ
Application
ELISA, IF

Basic Information

Immunogen
Partial recombinant corresponding to aa. 2-86 from human RPL21 (NP_000973) with GST tag
Specificity
Human
Antibody Isotype
IgG2b, κ
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.2

Target

Full Name
ribosomal protein L21
Introduction
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L21E family of ribosomal proteins. It is located in the cytoplasm. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]
Entrez Gene ID
6144
UniProt ID
P46778
Alternative Names
Ribosomal Protein L21; Large Ribosomal Subunit Protein EL21; 0S Ribosomal Protein L21; HYPT12; L21;
Function
Component of the large ribosomal subunit (PubMed:12962325, PubMed:23636399, PubMed:25957688, PubMed:25901680).
The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:12962325, PubMed:23636399, PubMed:25957688, PubMed:25901680).
Biological Process
Biological Process cytoplasmic translation1 PublicationIC:FlyBase
Biological Process translationManual Assertion Based On ExperimentTAS:ProtInc
Cellular Location
Cytoplasm, cytosol
Cytoplasm
Endoplasmic reticulum
Detected on cytosolic polysomes (PubMed:25957688).
Detected in ribosomes that are associated with the rough endoplasmic reticulum (By similarity).
Involvement in disease
Hypotrichosis 12 (HYPT12):
A form of hypotrichosis, a condition characterized by the presence of less than the normal amount of hair and abnormal hair follicles and shafts, which are thin and atrophic. The extent of scalp and body hair involvement can be very variable, within as well as between families. HYPT12 patients have normal scalp hair density at birth. Hair loss begins during the first 6 months of life and gradually progresses to nearly complete loss of scalp hair. The remaining hairs grow slowly and are thin, sparse, dry, and fragile. Body hair, axillary and pubic hair, eyebrows and eyelashes are also sparse or absent. HYPT12 inheritance is autosomal dominant.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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