Rabbit Anti-RPL26 Recombinant Antibody (D8F6) (CBMAB-R3375-CN)

Name: Rabbit Anti-RPL26 Recombinant Antibody (D8F6)
SKU: CBMAB-R3375-CN
Rating: 5 (1 reviews)

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Datasheet

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Basic Information

Host Animal

Rabbit

Clone

D8F6

Application

Specificity

Human, Mouse, Rat, Monkey

Antibody Isotype

IgG

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

More Infomation

Target

Full Name

Ribosomal Protein L26

Introduction

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L24P family of ribosomal proteins. It is located in the cytoplasm. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. Mutations in this gene result in Diamond-Blackfan anemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015]

Entrez Gene ID

Human	6154
Mouse	19941
Rat	287417
Monkey	717378

UniProt ID

Human	P61254
Mouse	P61255
Rat	P12749
Monkey	F7F4S1

Alternative Names

Ribosomal Protein L26; Large Ribosomal Subunit Protein UL24; 0S Ribosomal Protein L26; DBA11; L26;

Function

Component of the large ribosomal subunit (PubMed:26100019, PubMed:23636399, PubMed:32669547).
The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:26100019, PubMed:23636399, PubMed:32669547).

Biological Process

Biological Process cellular response to gamma radiationManual Assertion Based On ExperimentIDA:CAFA
Biological Process cellular response to UVManual Assertion Based On ExperimentIMP:CAFA
Biological Process cytoplasmic translationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrestManual Assertion Based On ExperimentIMP:CAFA
Biological Process positive regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediatorManual Assertion Based On ExperimentIMP:CAFA
Biological Process positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediatorManual Assertion Based On ExperimentIMP:CAFA
Biological Process positive regulation of translationManual Assertion Based On ExperimentIMP:CAFA
Biological Process regulation of translation involved in cellular response to UVManual Assertion Based On ExperimentIMP:CAFA
Biological Process ribosomal large subunit biogenesisManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process rRNA processingManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process translationManual Assertion Based On ExperimentTAS:ProtInc

Cellular Location

Cytoplasm

Involvement in disease

Diamond-Blackfan anemia 11 (DBA11):
A form of Diamond-Blackfan anemia, a congenital non-regenerative hypoplastic anemia that usually presents early in infancy. Diamond-Blackfan anemia is characterized by a moderate to severe macrocytic anemia, erythroblastopenia, and an increased risk of malignancy. 30 to 40% of Diamond-Blackfan anemia patients present with short stature and congenital anomalies, the most frequent being craniofacial (Pierre-Robin syndrome and cleft palate), thumb and urogenital anomalies.

PTM

Ufmylated by UFL1 in response to endoplasmic reticulum stress, promoting reticulophagy of endoplasmic reticulum sheets.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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