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Rabbit Anti-RPL26 Recombinant Antibody (D8F6) (CBMAB-R3375-CN)

This product is a Rabbit antibody that recognizes RPL26. The antibody D8F6 can be used for immunoassay techniques such as: WB.
See all RPL26 antibodies

Summary

Host Animal
Rabbit
Specificity
Human, Mouse, Rat, Monkey
Clone
D8F6
Antibody Isotype
IgG
Application
WB

Basic Information

Specificity
Human, Mouse, Rat, Monkey
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Target

Full Name
Ribosomal Protein L26
Introduction
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L24P family of ribosomal proteins. It is located in the cytoplasm. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. Mutations in this gene result in Diamond-Blackfan anemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2015]
Entrez Gene ID
Human6154
Mouse19941
Rat287417
Monkey717378
UniProt ID
HumanP61254
MouseP61255
RatP12749
MonkeyF7F4S1
Alternative Names
Ribosomal Protein L26; Large Ribosomal Subunit Protein UL24; 0S Ribosomal Protein L26; DBA11; L26;
Function
Component of the large ribosomal subunit (PubMed:26100019, PubMed:23636399, PubMed:32669547).
The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:26100019, PubMed:23636399, PubMed:32669547).
Biological Process
Biological Process cellular response to gamma radiationManual Assertion Based On ExperimentIDA:CAFA
Biological Process cellular response to UVManual Assertion Based On ExperimentIMP:CAFA
Biological Process cytoplasmic translationManual Assertion Based On ExperimentIBA:GO_Central
Biological Process DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrestManual Assertion Based On ExperimentIMP:CAFA
Biological Process positive regulation of DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediatorManual Assertion Based On ExperimentIMP:CAFA
Biological Process positive regulation of intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediatorManual Assertion Based On ExperimentIMP:CAFA
Biological Process positive regulation of translationManual Assertion Based On ExperimentIMP:CAFA
Biological Process regulation of translation involved in cellular response to UVManual Assertion Based On ExperimentIMP:CAFA
Biological Process ribosomal large subunit biogenesisManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process rRNA processingManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process translationManual Assertion Based On ExperimentTAS:ProtInc
Cellular Location
Cytoplasm
Involvement in disease
Diamond-Blackfan anemia 11 (DBA11):
A form of Diamond-Blackfan anemia, a congenital non-regenerative hypoplastic anemia that usually presents early in infancy. Diamond-Blackfan anemia is characterized by a moderate to severe macrocytic anemia, erythroblastopenia, and an increased risk of malignancy. 30 to 40% of Diamond-Blackfan anemia patients present with short stature and congenital anomalies, the most frequent being craniofacial (Pierre-Robin syndrome and cleft palate), thumb and urogenital anomalies.
PTM
Ufmylated by UFL1 in response to endoplasmic reticulum stress, promoting reticulophagy of endoplasmic reticulum sheets.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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