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Mouse Anti-RPL7 Recombinant Antibody (CBCNR-722) (CBMAB-R3397-CN)


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Summary

Host Animal
Mouse
Specificity
Human
Clone
CBCNR-722
Antibody Isotype
IgG2a, κ
Application
IF, ELISA

Basic Information

Immunogen
RPL7 (NP_000962.2, aa. 158-248) partial recombinant protein with GST tag
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
1× PBS, pH 7.2

Target

Full Name
ribosomal protein L7
Introduction
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein belongs to the L30P family of ribosomal proteins. It contains an N-terminal basic region-leucine zipper (BZIP)-like domain and the RNP consensus submotif RNP2. In vitro the BZIP-like domain mediates homodimerization and stable binding to DNA and RNA, with a preference for 28S rRNA and mRNA. The protein can inhibit cell-free translation of mRNAs, suggesting that it plays a regulatory role in the translation apparatus. It is located in the cytoplasm. The protein has been shown to be an autoantigen in patients with systemic autoimmune diseases, such as systemic lupus erythematosus. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]
Entrez Gene ID
6129
UniProt ID
P18124
Alternative Names
Ribosomal Protein L7; Large Ribosomal Subunit Protein UL30; 0S Ribosomal Protein L7; HumL7-1; L7;
Function
Component of the large ribosomal subunit (PubMed:12962325, PubMed:23636399, PubMed:32669547).
The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:12962325, PubMed:23636399, PubMed:32669547).
Binds to G-rich structures in 28S rRNA and in mRNAs (PubMed:12962325).
Plays a regulatory role in the translation apparatus; inhibits cell-free translation of mRNAs (PubMed:12962325).
Biological Process
Biological Process cytoplasmic translation1 PublicationIC:FlyBase
Biological Process maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)Manual Assertion Based On ExperimentIBA:GO_Central
Biological Process ribosomal large subunit biogenesisManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process rRNA processingManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process translationManual Assertion Based On ExperimentTAS:ProtInc
Cellular Location
Cytoplasm
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For research use only. Not intended for any clinical use.

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