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Mouse Anti-RPS17 Recombinant Antibody (CBCNR-743) (CBMAB-R3458-CN)


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Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat
Clone
CBCNR-743
Antibody Isotype
IgG1, κ
Application
WB, ELISA, WB

Basic Information

Immunogen
RPS17 (NP_001012, aa. 36-135) partial recombinant protein with GST tag
Specificity
Human, Mouse, Rat
Antibody Isotype
IgG1, κ
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
Ascites

Target

Full Name
ribosomal protein S17
Introduction
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of four RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S17E family of ribosomal proteins and is located in the cytoplasm. Mutations in this gene cause Diamond-Blackfan anemia 4. Alternative splicing of this gene results in multiple transcript variants. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Apr 2014]
Entrez Gene ID
Human6218
Mouse20068
Rat29286
UniProt ID
HumanP08708
MouseP63276
RatP04644
Alternative Names
Ribosomal Protein S17; Small Ribosomal Subunit Protein ES17; RPS17L; Ribosomal Protein S17-Like; 40S Ribosomal Protein S17; RPS17L1; RPS17L2; DBA4; S17;
Biological Process
Biological Process cytoplasmic translation1 PublicationIC:FlyBase
Biological Process erythrocyte homeostasisManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process ribosomal small subunit biogenesisManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process rRNA processingManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process translation1 PublicationIC:UniProtKB
Biological Process translational initiation1 PublicationNAS:UniProtKB
Cellular Location
cytoplasm
cytosol
cytosolic ribosome
cytosolic small ribosomal subunit
focal adhesion
membrane
nucleoplasm
ribosome
synapse
Involvement in disease
Diamond-Blackfan anemia 4 (DBA4):
A form of Diamond-Blackfan anemia, a congenital non-regenerative hypoplastic anemia that usually presents early in infancy. Diamond-Blackfan anemia is characterized by a moderate to severe macrocytic anemia, erythroblastopenia, and an increased risk of developing leukemia. 30 to 40% of Diamond-Blackfan anemia patients present with short stature and congenital anomalies, the most frequent being craniofacial (Pierre-Robin syndrome and cleft palate), thumb and urogenital anomalies.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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