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Mouse Anti-RPS2 Recombinant Antibody (3G6) (CBMAB-R3465-CN)

This product is a Mouse antibody that recognizes RPS2. The antibody 3G6 can be used for immunoassay techniques such as: ELISA, IF, IHC, WB.
See all RPS2 antibodies
Published Data
Fig.1 Time-dependent western blot analysis of total rpS2 protein expression.
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Fig.2 PRMT3 is indispensable for maintaining rpS2 stability.
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Fig.3 PRMT3 and rpS2 are regulators of spine morphogenesis in hippocampal neurons.
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Summary

Host Animal
Mouse
Specificity
Human
Clone
3G6
Antibody Isotype
IgG2a, κ
Application
ELISA, IF, IHC, WB

Basic Information

Immunogen
Partial recombinant corresponding to aa. 198-294 from human RPS2 (NP_002943) with GST tag
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.2

Target

Full Name
ribosomal protein S2
Introduction
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S5P family of ribosomal proteins. It is located in the cytoplasm. This gene shares sequence similarity with mouse LLRep3. It is co-transcribed with the small nucleolar RNA gene U64, which is located in its third intron. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]
Entrez Gene ID
6187
UniProt ID
P15880
Alternative Names
Ribosomal Protein S2; Small Ribosomal Subunit Protein US5; 40S Ribosomal Protein S4; Protein LLRep3; 40S Ribosomal Protein S2; OK/KNS-Cl.6; LLREP3; RPS4; S2;
Function
Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel. Plays a role in the assembly and function of the 40S ribosomal subunit. Mutations in this protein affects the control of translational fidelity. Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly.
Biological Process
Biological Process cytoplasmic translation1 PublicationIC:FlyBase
Biological Process positive regulation of ubiquitin-protein transferase activityManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process translationManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
cytoplasm
cytosol
cytosolic ribosome
cytosolic small ribosomal subunit
extracellular exosome
focal adhesion
membrane
nucleoplasm
nucleus
PTM
Citrullinated by PADI4 in the Arg/Gly-rich region.
Asymmetric arginine dimethylation by PRMT3 oCcurs at multiple sites in the Arg/Gly-rich region.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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