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Mouse Anti-RPS27 Recombinant Antibody (CBFYM-3096) (CBMAB-M3292-FY)

This product is mouse antibody that recognizes RPS27. The antibody CBFYM-3096 can be used for immunoassay techniques such as: IF.
See all RPS27 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBFYM-3096
Antibody Isotype
IgG1
Application
IF

Basic Information

Immunogen
Recombinant fragment of MPS1 expressed in E. coli
Specificity
Human
Antibody Isotype
IgG1
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.4
Preservative
0.03% Sodium azide
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Ribosomal Protein S27
Introduction
Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of four RNA species and approximately 80 structurally distinct proteins. This gene encodes a member of the S27e family of ribosomal proteins and component of the 40S subunit. The encoded protein contains a C4-type zinc finger domain that can bind to zinc and may bind to nucleic acid. Studies in rat indicate that ribosomal protein S27 is located near ribosomal protein S18 in the 40S subunit and is covalently linked to translation initiation factor eIF3. Mutations in this gene have been identified in numerous melanoma patients and in at least one patient with Diamond-Blackfan anemia. Elevated expression of this gene has been observed in various human cancers. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.
Entrez Gene ID
6232
UniProt ID
P42677
Alternative Names
Ribosomal Protein S27; Small Ribosomal Subunit Protein ES27; Metallopan-Stimulin 1; Metallopanstimulin 1; MPS-1; MPS1
Function
Component of the small ribosomal subunit (PubMed:8706699).
Required for proper rRNA processing and maturation of 18S rRNAs (PubMed:25424902).
Biological Process
Biological Process cytoplasmic translation1 PublicationIC:FlyBase
Biological Process ribosomal small subunit assemblyManual Assertion Based On ExperimentIBA:GO_Central
Biological Process rRNA processingManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process translation1 PublicationNAS:UniProtKB
Cellular Location
cytosol
cytosolic ribosome
cytosolic small ribosomal subunit
nucleoplasm
nucleus
postsynaptic density
ribosome
Involvement in disease
Diamond-Blackfan anemia 17 (DBA17):
A form of Diamond-Blackfan anemia, a congenital non-regenerative hypoplastic anemia that usually presents early in infancy. Diamond-Blackfan anemia is characterized by a moderate to severe macrocytic anemia, erythroblastopenia, and an increased risk of malignancy. 30 to 40% of Diamond-Blackfan anemia patients present with short stature and congenital anomalies, the most frequent being craniofacial (Pierre-Robin syndrome and cleft palate), thumb and urogenital anomalies.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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