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Recombinant Mouse Anti-RRAS2 Antibody (CBAb217) (CBMAB-Ab217-LY)

The product is antibody recognizes RRAS2. The antibody CBAb217 immunoassay techniques such as: WB 1:500-1:1000.
See all RRAS2 antibodies

Summary

Host Animal
Mouse
Specificity
Human, Mouse
Clone
CBAb217
Antibody Isotype
IgG
Application
WB 1:500-1:1000

Basic Information

Immunogen
A synthetic Peptide of human RRAS2
Specificity
Human, Mouse
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Preservative
0.02% sodium azide
Purity
> 95% Purity determined by SDS-PAGE.
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freezethaw cycles.

Target

Full Name
RAS related 2
Introduction
This gene encodes a member of the R-Ras subfamily of Ras-like small GTPases. The encoded protein associates with the plasma membrane and may function as a signal transducer. This protein may play an important role in activating signal transduction pathways that control cell proliferation. Mutations in this gene are associated with the growth of certain tumors. Pseudogenes of this gene are found on chromosomes 1 and 2. Alternate splicing results in multiple transcript variants.
Entrez Gene ID
Human22800
Mouse66922
UniProt ID
HumanP62070
MouseP62071
Alternative Names
RRAS2; TC21; ras-related protein R-Ras2
Function
GTP-binding protein with GTPase activity involved in the regulation of MAPK signaling pathway, thereby controlling multiple cellular processes (PubMed:31130282).
Involved in the regulation of MAPK signaling pathway (PubMed:31130282, PubMed:31130285).
Regulation of craniofacial development (PubMed:31130282, PubMed:31130285).
Biological Process
Biological Process osteoblast differentiationManual Assertion Based On ExperimentHDA:UniProtKB
Biological Process positive regulation of Schwann cell migrationIEA:Ensembl
Biological Process Ras protein signal transductionManual Assertion Based On ExperimentIBA:GO_Central
Biological Process regulation of neuron deathManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process Schwann cell migrationIEA:Ensembl
Cellular Location
Cell membrane
Golgi apparatus membrane
Involvement in disease
Ovarian cancer (OC):
The term ovarian cancer defines malignancies originating from ovarian tissue. Although many histologic types of ovarian tumors have been described, epithelial ovarian carcinoma is the most common form. Ovarian cancers are often asymptomatic and the recognized signs and symptoms, even of late-stage disease, are vague. Consequently, most patients are diagnosed with advanced disease.
Noonan syndrome 12 (NS12):
A form of Noonan syndrome, a disease characterized by short stature, facial dysmorphic features such as hypertelorism, a downward eyeslant and low-set posteriorly rotated ears, and a high incidence of congenital heart defects and hypertrophic cardiomyopathy. Other features can include a short neck with webbing or redundancy of skin, deafness, motor delay, variable intellectual deficits, multiple skeletal defects, cryptorchidism, and bleeding diathesis. Individuals with Noonan syndrome are at risk of juvenile myelomonocytic leukemia, a myeloproliferative disorder characterized by excessive production of myelomonocytic cells. NS12 inheritance is autosomal dominant. There is considerable variability in severity.
PTM
May be post-translationally modified by both palmitoylation and polyisoprenylation.
Fatty-acylation at Lys-192, Lys-194; lys-196 and Lys-197 is required for localization to the plasma membrane and activity (PubMed:28406396).
Defatty-acylated by SIRT6, affecting its localization to the plasma membrane (PubMed:28406396).
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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