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Rat Anti-RSPO4 Recombinant Antibody (8H192) (CBMAB-R3757-CN)


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Summary

Host Animal
Rat
Specificity
Mouse
Clone
8H192
Antibody Isotype
IgG2b
Application
ELISA, WB

Basic Information

Immunogen
Recombinant corresponding to aa. 21-197 of mouse RSPO-4 expressed in E. coli (Q8BJ73)
Specificity
Mouse
Antibody Isotype
IgG2b
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
LYOPH
Buffer
PBS, 5% Trehalose
Concentration
0.5 mg/mL

Target

Full Name
R-Spondin 4
Introduction
This gene encodes a member of the R-spondin family of proteins that share a common domain organization consisting of a signal peptide, cysteine-rich/furin-like domain, thrombospondin domain and a C-terminal basic region. The encoded protein may be involved in activation of Wnt/beta-catenin signaling pathways. Mutations in this gene are associated with anonychia congenital. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2009]
Entrez Gene ID
228770
UniProt ID
Q8BJ73
Alternative Names
R-Spondin 4; Roof Plate-Specific Spondin-4; R-Spondin Family, Member 4; C20orf182; HRspo4; Chromosome 20 Open Reading Frame 182; R-Spondin-4; CRISTIN4;
Function
Activator of the canonical Wnt signaling pathway by acting as a ligand for LGR4-6 receptors (PubMed:29769720).
Upon binding to LGR4-6 (LGR4, LGR5 or LGR6), LGR4-6 associate with phosphorylated LRP6 and frizzled receptors that are activated by extracellular Wnt receptors, triggering the canonical Wnt signaling pathway to increase expression of target genes. Also regulates the canonical Wnt/beta-catenin-dependent pathway and non-canonical Wnt signaling by acting as an inhibitor of ZNRF3, an important regulator of the Wnt signaling pathway (PubMed:21727895, PubMed:21909076).
Biological Process
Biological Process nail developmentManual Assertion Based On ExperimentIMP:MGI
Biological Process positive regulation of Wnt signaling pathwayManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process Wnt signaling pathwayIEA:UniProtKB-KW
Cellular Location
Secreted
Involvement in disease
Nail disorder, non-syndromic congenital, 4 (NDNC4):
A nail disorder characterized by congenital anonychia or its milder phenotypic variant hyponychia. Anonychia/hyponychia is the absence or severe hypoplasia of all fingernails and toenails without significant bone anomalies.
PTM
Tyr-112 may be phosphorylated; however as this position is probably extracellular, the vivo relevance is not proven.
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For research use only. Not intended for any clinical use.

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