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Mouse Anti-RTN2 Recombinant Antibody (CBCNR-849) (CBMAB-R3800-CN)

This product is a Mouse antibody that recognizes RTN2. The antibody CBCNR-849 can be used for immunoassay techniques such as: ELISA, WB.
See all RTN2 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBCNR-849
Antibody Isotype
IgG2a, κ
Application
ELISA, WB

Basic Information

Immunogen
RTN2 (NP_005610, aa. 1-100) partial recombinant protein with GST tag
Specificity
Human
Antibody Isotype
IgG2a, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Buffer
1× PBS, pH 7.2

Target

Full Name
Reticulon 2
Introduction
This gene belongs to the family of reticulon encoding genes. Reticulons are necessary for proper generation of tubular endoplasmic reticulum and likely play a role in intracellular vesicular transport. Alternatively spliced transcript variants encoding different isoforms have been identified. Mutations at this locus have been associated with autosomal dominant spastic paraplegia-12. [provided by RefSeq, Apr 2012]
Entrez Gene ID
6253
UniProt ID
O75298
Alternative Names
Reticulon 2; NSP-Like Protein 1; Neuroendocrine-Specific Protein-Like 1; Neuroendocrine-Specific Protein-Like I; NSP-Like Protein I; NSPL1;
Function
Inhibits amyloid precursor protein processing, probably by blocking BACE1 activity (PubMed:15286784).
Enhances trafficking of the glutamate transporter SLC1A1/EAAC1 from the endoplasmic reticulum to the cell surface (By similarity).
Plays a role in the translocation of SLC2A4/GLUT4 from intracellular membranes to the cell membrane which facilitates the uptake of glucose into the cell (By similarity).
Biological Process
Biological Process gene expressionIEA:Ensembl
Biological Process intracellular protein transmembrane transportISS:UniProtKB
Biological Process negative regulation of amyloid-beta formationManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process regulation of glucose importISS:UniProtKB
Cellular Location
Endoplasmic reticulum membrane
Sarcoplasmic reticulum membrane
Cell membrane
Cell membrane, sarcolemma
Cell membrane, sarcolemma, T-tubule
Cytoplasm, myofibril, sarcomere, Z line
Cytoplasm, cytoskeleton
Localizes to intermediate filaments in mononucleated myoblasts and to Z lines in mature myotubes.
Involvement in disease
Spastic paraplegia 12, autosomal dominant (SPG12):
A form of spastic paraplegia, a neurodegenerative disorder characterized by a slow, gradual, progressive weakness and spasticity of the lower limbs. Rate of progression and the severity of symptoms are quite variable. Initial symptoms may include difficulty with balance, weakness and stiffness in the legs, muscle spasms, and dragging the toes when walking. In some forms of the disorder, bladder symptoms (such as incontinence) may appear, or the weakness and stiffness may spread to other parts of the body.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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