Mouse Anti-RTN4IP1 Recombinant Antibody (D-2) (CBMAB-N4227-WJ)

Name: Mouse Anti-RTN4IP1 Recombinant Antibody (D-2)
SKU: CBMAB-N4227-WJ
Rating: 5 (1 reviews)

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Datasheet

SDS

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Datasheet Target Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Mouse

Clone

D-2

Application

WB, IP, IF, ELISA

Specificity

Human, Rat, Mouse

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Reticulon 4 Interacting Protein 1

Introduction

This gene encodes a mitochondrial protein that interacts with reticulon 4, which is a potent inhibitor of regeneration following spinal cord injury. This interaction may be important for reticulon-induced inhibition of neurite growth. Mutations in this gene can cause optic atrophy 10, with or without ataxia, cognitive disability, and seizures. There is a pseudogene for this gene on chromosome 12. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]

Entrez Gene ID

Human	84816
Mouse	170728
Rat	309912

UniProt ID

Human	Q8WWV3
Mouse	Q924D0
Rat	B2GUZ6

Alternative Names

Reticulon 4 Interacting Protein 1; NOGO-Interacting Mitochondrial Protein; NIMP; Reticulon-4-Interacting Protein 1, Mitochondrial; OPA10;

Function

Plays a role in the regulation of retinal ganglion cell (RGC) neurite outgrowth, and hence in the development of the inner retina and optic nerve. Appears to be a potent inhibitor of regeneration following spinal cord injury.

Biological Process

Biological Process nervous system developmentIEA:UniProtKB-KW
Biological Process regulation of dendrite developmentISS:UniProtKB

Cellular Location

Mitochondrion outer membrane
Colocalizes with the endoplasmic reticulum HSPA5 at spots corresponding to contacts with mitochondria.

Involvement in disease

Optic atrophy 10 with or without ataxia, intellectual disability, and seizures (OPA10):
An autosomal recessive disease characterized by progressive visual loss in association with optic atrophy. Atrophy of the optic disk indicates a deficiency in the number of nerve fibers which arise in the retina and converge to form the optic disk, optic nerve, optic chiasm and optic tracts. OPA10 patients may also manifest mild ataxia, mild intellectual disability and, rarely, generalized seizures.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

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We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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