Mouse Anti-S. cerevisiae CDC6 Recombinant Antibody (9H8/5) (CBMAB-V208-0081-CQ)

Name: Mouse Anti-S. cerevisiae CDC6 Recombinant Antibody (9H8/5)
SKU: CBMAB-V208-0081-CQ
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

9H8/5

Application

WB, IHC, IP

Immunogen

Cdc6 from S.Cerevisiae

Specificity

S. cerevisiae

Antibody Isotype

IgG1

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

AAA family ATPase CDC6

Introduction

Plays a crucial role in forming the pre-replicative complexes. Interacts with the origin recognition complex (ORC) and MCM2-7 helicase complex leading to the linking of those complexes and loading of the replicative helicase MCM2-7 onto the pre-replicative complexes. Required for the initiation of DNA replication and then actively participates in the suppression of nuclear division.

Entrez Gene ID

853244

UniProt ID

P09119

Alternative Names

CDC6; YJL194W; AAA family ATPase CDC6

Function

Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated.

Biological Process

Cell division Source: UniProtKB-KW
Cellular response to angiotensin Source: Ensembl
Cellular response to vasopressin Source: Ensembl
DNA replication Source: Reactome
DNA replication checkpoint Source: ProtInc
DNA replication initiation Source: Reactome
Mitotic cell cycle Source: UniProtKB
Mitotic DNA replication checkpoint Source: GO_Central
Negative regulation of cell population proliferation Source: ProtInc
Negative regulation of DNA replication Source: ProtInc
Positive regulation of chromosome segregation Source: BHF-UCL
Positive regulation of cyclin-dependent protein serine/threonine kinase activity Source: Ensembl
Positive regulation of cytokinesis Source: BHF-UCL
Positive regulation of fibroblast proliferation Source: Ensembl
Pre-replicative complex assembly Source: Reactome
Regulation of cyclin-dependent protein serine/threonine kinase activity Source: ProtInc
Regulation of mitotic metaphase/anaphase transition Source: BHF-UCL
Regulation of transcription involved in G1/S transition of mitotic cell cycle Source: Reactome
Traversing start control point of mitotic cell cycle Source: ProtInc

Cellular Location

Nucleus; Cytoplasm. The protein is nuclear in G1 and cytoplasmic in S-phase cells (PubMed:9566895).

Involvement in disease

Meier-Gorlin syndrome 5 (MGORS5): A syndrome characterized by bilateral microtia, aplasia/hypoplasia of the patellae, and severe intrauterine and postnatal growth retardation with short stature and poor weight gain. Additional clinical findings include anomalies of cranial sutures, microcephaly, apparently low-set and simple ears, microstomia, full lips, highly arched or cleft palate, micrognathia, genitourinary tract anomalies, and various skeletal anomalies. While almost all cases have primordial dwarfism with substantial prenatal and postnatal growth retardation, not all cases have microcephaly, and microtia and absent/hypoplastic patella are absent in some. Despite the presence of microcephaly, intellect is usually normal.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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