Mouse Anti-S100A12 Recombinant Antibody (CBFYA-0248) (CBMAB-X0356-FY)

Name: Mouse Anti-S100A12 Recombinant Antibody (CBFYA-0248)
SKU: CBMAB-X0356-FY
Rating: 5 (1 reviews)

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Datasheet

SDS

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Basic Information

Host Animal

Mouse

Clone

CBFYA-0248

Application

Immunoassay, WB

Immunogen

Recombinant S100A12

Specificity

Human

Antibody Isotype

IgG2a

Clonality

Monoclonal

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format

Liquid

Buffer

PBS, 0.1% BSA

Preservative

0.02% Sodium azide

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

S100 Calcium Binding Protein A12

Introduction

The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein is proposed to be involved in specific calcium-dependent signal transduction pathways and its regulatory effect on cytoskeletal components may modulate various neutrophil activities. The protein includes an antimicrobial peptide which has antibacterial activity.

Entrez Gene ID

6283

UniProt ID

P80511

Alternative Names

S100 Calcium Binding Protein A12; Extracellular Newly Identified RAGE-Binding Protein; Migration Inhibitory Factor-Related Protein 6; Calcium-Binding Protein In Amniotic Fluid 1; Neutrophil S100 Protein; EN-RAGE; CAAF1; MRP-6; CGRP; CAGC; P6

Function

S100A12 is a calcium-, zinc- and copper-binding protein which plays a prominent role in the regulation of inflammatory processes and immune response. Its pro-inflammatory activity involves recruitment of leukocytes, promotion of cytokine and chemokine production, and regulation of leukocyte adhesion and migration. Acts as an alarmin or a danger associated molecular pattern (DAMP) molecule and stimulates innate immune cells via binding to receptor for advanced glycation endproducts (AGER). Binding to AGER activates the MAP-kinase and NF-kappa-B signaling pathways leading to production of pro-inflammatory cytokines and up-regulation of cell adhesion molecules ICAM1 and VCAM1. Acts as a monocyte and mast cell chemoattractant. Can stimulate mast cell degranulation and activation which generates chemokines, histamine and cytokines inducing further leukocyte recruitment to the sites of inflammation. Can inhibit the activity of matrix metalloproteinases; MMP2, MMP3 and MMP9 by chelating Zn2+ from their active sites. Possesses filariacidal and filariastatic activity. Calcitermin possesses antifungal activity against C.albicans and is also active against E.coli and P.aeruginosa but not L.monocytogenes and S.aureus.

Biological Process

Biological Process antimicrobial humoral immune response mediated by antimicrobial peptideManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process defense response to bacteriumManual Assertion Based On ExperimentTAS:UniProtKB
Biological Process defense response to fungusManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process inflammatory responseManual Assertion Based On ExperimentTAS:ProtInc
Biological Process innate immune responseManual Assertion Based On ExperimentTAS:UniProtKB
Biological Process killing of cells of another organismManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process mast cell activationManual Assertion Based On ExperimentTAS:UniProtKB
Biological Process monocyte chemotaxisManual Assertion Based On ExperimentTAS:UniProtKB
Biological Process neutrophil chemotaxisManual Assertion Based On ExperimentTAS:UniProtKB
Biological Process positive regulation of I-kappaB kinase/NF-kappaB signalingManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process positive regulation of inflammatory responseManual Assertion Based On ExperimentTAS:UniProtKB
Biological Process positive regulation of MAP kinase activityManual Assertion Based On ExperimentTAS:UniProtKB
Biological Process positive regulation of NF-kappaB transcription factor activityManual Assertion Based On ExperimentTAS:UniProtKB
Biological Process xenobiotic metabolic processManual Assertion Based On ExperimentIDA:UniProtKB

Cellular Location

Secreted
Cytoplasm
Cytoplasm, cytoskeleton
Cell membrane
Predominantly localized in the cytoplasm. Upon elevation of the intracellular calcium level, translocated from the cytoplasm to the cytoskeleton and the cell membrane. Upon neutrophil activation is secreted via a microtubule-mediated, alternative pathway.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

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Isotype control

For research use only. Not intended for any clinical use.

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We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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