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Mouse Anti-SAP18 Recombinant Antibody (CBXS-4768) (CBMAB-S1995-CQ)

This product is a mouse antibody that recognizes SAP18. The antibody CBXS-4768 can be used for immunoassay techniques such as: ELISA, ICC, IF.
See all SAP18 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXS-4768
Antibody Isotype
IgG1, κ
Application
ELISA, ICC, IF

Basic Information

Immunogen
SAP18 (AAH30836, 1 a.a.-153 a.a) Full length recombinant protein with GST tag
Specificity
Human
Antibody Isotype
IgG1, κ
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.4
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Sin3A-associated protein, 18kDa
Introduction
Histone acetylation plays a key role in the regulation of eukaryotic gene expression. Histone acetylation and deacetylation are catalyzed by multisubunit complexes. The protein encoded by this gene is a component of the histone deacetylase complex, which includes SIN3, SAP30, HDAC1, HDAC2, RbAp46, RbAp48, and other polypeptides. This protein directly interacts with SIN3 and enhances SIN3-mediated transcriptional repression when tethered to the promoter. A pseudogene has been identified on chromosome 2.
Entrez Gene ID
10284
UniProt ID
O00422
Alternative Names
Sin3A Associated Protein 18; Cell Growth-Inhibiting Gene 38 Protein; 18 KDa Sin3-Associated Polypeptide; Sin3A-Associated Protein, 18kDa; 2HOR0202; Histone Deacetlyase Complex Subunit SAP18; Histone Deacetylase Complex Subunit SAP18;
Function
Component of the SIN3-repressing complex. Enhances the ability of SIN3-HDAC1-mediated transcriptional repression. When tethered to the promoter, it can direct the formation of a repressive complex to core histone proteins. Auxiliary component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Component of the ASAP and PSAP complexes which bind RNA in a sequence-independent manner and are proposed to be recruited to the EJC prior to or during the splicing process and to regulate specific excision of introns in specific transcription subsets. The ASAP complex can inhibit mRNA processing during in vitro splicing reactions. The ASAP complex promotes apoptosis and is disassembled after induction of apoptosis. Involved in the splicing modulation of BCL2L1/Bcl-X (and probably other apoptotic genes); specifically inhibits the formation of proapoptotic isoforms such as Bcl-X(S); the activity is different from the established EJC assembly and function.
Biological Process
Biological Process mRNA processingIEA:UniProtKB-KW
Biological Process negative regulation of DNA-templated transcriptionManual Assertion Based On ExperimentIBA:GO_Central
Biological Process negative regulation of mRNA splicing, via spliceosomeManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process positive regulation of apoptotic processManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process regulation of alternative mRNA splicing, via spliceosomeManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentTAS:ProtInc
Biological Process RNA splicingIEA:UniProtKB-KW
Cellular Location
Nucleus
Cytoplasm
Nucleus speckle
Shuttles between the nucleus and the cytoplasm (PubMed:16314458).
Colocalizes with ACIN1 and SRSF2 in nuclear speckles (PubMed:20966198).
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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