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Mouse Anti-SAP30 Recombinant Antibody (CBXS-3194) (CBMAB-S5935-CQ)

This product is a mouse antibody that recognizes SAP30. The antibody CBXS-3194 can be used for immunoassay techniques such as: ELISA, IF, IHC, WB.
See all SAP30 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXS-3194
Antibody Isotype
IgG2b, κ
Application
ELISA, IF, IHC, WB

Basic Information

Immunogen
Partial recombinant corresponding to aa131-220 from SAP30 (NP_003855) with GST tag
Specificity
Human
Antibody Isotype
IgG2b, κ
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.2
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Sin3A-associated protein, 30kDa
Introduction
Histone acetylation plays a key role in the regulation of eukaryotic gene expression. Histone acetylation and deacetylation are catalyzed by multisubunit complexes. The protein encoded by this gene is a component of the histone deacetylase complex, which includes SIN3, SAP18, HDAC1, HDAC2, RbAp46, RbAp48, and other polypeptides. This complex is active in deacetylating core histone octamers, but inactive in deacetylating nucleosomal histones. A pseudogene of this gene is located on chromosome 3.
Entrez Gene ID
8819
UniProt ID
O75446
Alternative Names
Sin3A Associated Protein 30; Sin3 Corepressor Complex Subunit SAP30; 30 KDa Sin3-Associated Polypeptide; Sin3A-Associated Protein, 30kDa; Sin3-Associated Polypeptide P30;
Function
Involved in the functional recruitment of the Sin3-histone deacetylase complex (HDAC) to a specific subset of N-CoR corepressor complexes. Capable of transcription repression by N-CoR. Active in deacetylating core histone octamers (when in a complex) but inactive in deacetylating nucleosomal histones.
(Microbial infection) Involved in transcriptional repression of HHV-1 genes TK and gC.
Biological Process
Biological Process modulation by host of symbiont transcriptionManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process negative regulation of cell migration1 PublicationIC:ComplexPortal
Biological Process negative regulation of stem cell population maintenance1 PublicationIC:ComplexPortal
Biological Process negative regulation of transcription by RNA polymerase IIManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process negative regulation of transforming growth factor beta receptor signaling pathway1 PublicationIC:ComplexPortal
Biological Process positive regulation of stem cell population maintenance1 PublicationIC:ComplexPortal
Biological Process regulation of DNA-templated transcriptionManual Assertion Based On ExperimentIBA:GO_Central
Biological Process skeletal muscle cell differentiationIEA:Ensembl
Cellular Location
Nucleus
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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