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Mouse Anti-SARNP Recombinant Antibody (CBXS-4267) (CBMAB-S1517-CQ)

This product is a mouse antibody that recognizes SARNP. The antibody CBXS-4267 can be used for immunoassay techniques such as: Dot, ICC, IF, WB.
See all SARNP antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXS-4267
Antibody Isotype
IgG2b
Application
Dot, ICC, IF, WB

Basic Information

Specificity
Human
Antibody Isotype
IgG2b
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.2, 1% BSA
Preservative
0.05% sodium azide
Concentration
0.1 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
SAP domain containing ribonucleoprotein
Introduction
This gene encodes a protein that is upregulated in response to various cytokines. The encoded protein may play a role in cell cycle progression. A translocation between this gene and the myeloid/lymphoid leukemia gene, resulting in expression of a chimeric protein, has been associated with acute myelomonocytic leukemia. Pseudogenes exist on chromosomes 7 and 8. Alternatively spliced transcript variants have been described.
Entrez Gene ID
84324
UniProt ID
P82979
Alternative Names
SAP Domain Containing Ribonucleoprotein; Cytokine-Induced Protein Of 29 KDa; Cytokine Induced Protein 29 KDa; Hepatocellular Carcinoma 1; Nuclear Protein Hcc-1; HCC1; Proliferation Associated Cytokine-Inducible Protein CIP29;
Function
Binds both single-stranded and double-stranded DNA with higher affinity for the single-stranded form. Specifically binds to scaffold/matrix attachment region DNA. Also binds single-stranded RNA. Enhances RNA unwinding activity of DDX39A. May participate in important transcriptional or translational control of cell growth, metabolism and carcinogenesis. Component of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway. The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production.
Biological Process
Biological Process mRNA export from nucleusManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process negative regulation of transcription by RNA polymerase IIIEA:Ensembl
Biological Process poly(A)+ mRNA export from nucleusManual Assertion Based On ExperimentIBA:GO_Central
Biological Process regulation of translationIEA:UniProtKB-KW
Cellular Location
Nucleus
Nucleus speckle
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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