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Rabbit Anti-SBF1 Recombinant Antibody (CBXS-1323) (CBMAB-S4182-CQ)

This product is a rabbit antibody that recognizes SBF1. The antibody CBXS-1323 can be used for immunoassay techniques such as: WB, FC.
See all SBF1 antibodies

Summary

Host Animal
Rabbit
Specificity
Mouse, Rat, Human
Clone
CBXS-1323
Antibody Isotype
IgG
Application
WB, FC

Basic Information

Specificity
Mouse, Rat, Human
Antibody Isotype
IgG
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
SET Binding Factor 1
Introduction
This gene encodes a member of the protein-tyrosine phosphatase family. However, the encoded protein does not appear to be a catalytically active phosphatase because it lacks several amino acids in the catalytic pocket. This protein contains a Guanine nucleotide exchange factor (GEF) domain which is necessary for its role in growth and differentiation. Mutations in this gene have been associated with Charcot-Marie-Tooth disease 4B3. Pseudogenes of this gene have been defined on chromosomes 1 and 8.
Entrez Gene ID
Human6305
Mouse77980
Rat300147
UniProt ID
HumanO95248
MouseQ6ZPE2
RatM0RAP5
Alternative Names
SET Binding Factor 1; DENN/MADD Domain Containing 7A; MTMR5; Myotubularin-Related Protein 5; Myotubularin Related 5; SET-Binding Factor 1; DENND7A; CMT4B3; Sbf1;
Function
Acts as an adapter for the phosphatase MTMR2 to regulate MTMR2 catalytic activity and subcellular location (PubMed:12668758).
May function as a guanine nucleotide exchange factor (GEF) activating RAB28 (PubMed:20937701).
Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form (PubMed:20937701).
Inhibits myoblast differentiation in vitro and induces oncogenic transformation in fibroblasts (PubMed:9537414).
Biological Process
Biological Process protein dephosphorylationManual Assertion Based On ExperimentTAS:UniProtKB
Biological Process regulation of GTPase activityIEA:InterPro
Biological Process spermatid developmentIEA:Ensembl
Cellular Location
Cytoplasm
Cytoplasm, perinuclear region
Involvement in disease
Charcot-Marie-Tooth disease 4B3 (CMT4B3):
A recessive demyelinating form of Charcot-Marie-Tooth disease, a disorder of the peripheral nervous system, characterized by progressive weakness and atrophy, initially of the peroneal muscles and later of the distal muscles of the arms. Charcot-Marie-Tooth disease is classified in two main groups on the basis of electrophysiologic properties and histopathology: primary peripheral demyelinating neuropathies (designated CMT1 when they are dominantly inherited) and primary peripheral axonal neuropathies (CMT2). Demyelinating neuropathies are characterized by severely reduced nerve conduction velocities (less than 38 m/sec), segmental demyelination and remyelination with onion bulb formations on nerve biopsy, slowly progressive distal muscle atrophy and weakness, absent deep tendon reflexes, and hollow feet. By convention autosomal recessive forms of demyelinating Charcot-Marie-Tooth disease are designated CMT4.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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