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Rabbit Anti-SCARB1 Recombinant Antibody (CBXS-0130) (CBMAB-S3121-CQ)

This product is a rabbit antibody that recognizes SCARB1. The antibody CBXS-0130 can be used for immunoassay techniques such as: WB, IHC.
See all SCARB1 antibodies

Summary

Host Animal
Rabbit
Specificity
Human, Mouse, Rat
Clone
CBXS-0130
Application
WB, IHC

Basic Information

Immunogen
Recombinant protein
Specificity
Human, Mouse, Rat
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Scavenger Receptor Class B Member 1
Introduction
The protein encoded by this gene is a plasma membrane receptor for high density lipoprotein cholesterol (HDL). The encoded protein mediates cholesterol transfer to and from HDL. In addition, this protein is a receptor for hepatitis C virus glycoprotein E2. Two transcript variants encoding different isoforms have been found for this gene.
Entrez Gene ID
Human949
Mouse20778
Rat25073
UniProt ID
HumanQ8WTV0
MouseQ61009
RatP97943
Alternative Names
Scavenger Receptor Class B Member 1; CD36 Antigen (Collagen Type I Receptor, Thrombospondin Receptor)-Like 1; CD36 And LIMPII Analogous 1; CD36L1; CLA-1; SR-BI; CLA1; SRB1;
Function
Receptor for different ligands such as phospholipids, cholesterol ester, lipoproteins, phosphatidylserine and apoptotic cells (PubMed:12016218, PubMed:12519372, PubMed:21226579).
Receptor for HDL, mediating selective uptake of cholesteryl ether and HDL-dependent cholesterol efflux (PubMed:26965621).
Also facilitates the flux of free and esterified cholesterol between the cell surface and apoB-containing lipoproteins and modified lipoproteins, although less efficiently than HDL. May be involved in the phagocytosis of apoptotic cells, via its phosphatidylserine binding activity (PubMed:12016218).
(Microbial infection) Acts as a receptor for hepatitis C virus in hepatocytes and appears to facilitate its cell entry (PubMed:12356718, PubMed:12913001, PubMed:18000990).
Binding between SCARB1 and the hepatitis C virus glycoprotein E2 is independent of the genotype of the viral isolate (PubMed:12356718).
(Microbial infection) Mediates uptake of M.fortuitum, E.coli and S.aureus.
(Microbial infection) Facilitates the entry of human coronavirus SARS-CoV-2 by acting as an entry cofactor through HDL binding.
Biological Process
Biological Process adhesion of symbiont to hostManual Assertion Based On ExperimentIMP:BHF-UCL
Biological Process blood vessel endothelial cell migrationIEA:Ensembl
Biological Process carotenoid transportIEA:Ensembl
Biological Process cholesterol catabolic processIEA:Ensembl
Biological Process cholesterol effluxManual Assertion Based On ExperimentIMP:AgBase
Biological Process cholesterol homeostasisISS:BHF-UCL
Biological Process cholesterol importManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process detection of lipopolysaccharideManual Assertion Based On ExperimentIDA:BHF-UCL
Biological Process endothelial cell proliferationIEA:Ensembl
Biological Process high-density lipoprotein particle clearanceManual Assertion Based On ExperimentIDA:BHF-UCL
Biological Process high-density lipoprotein particle remodelingISS:BHF-UCL
Biological Process intestinal lipid absorptionIEA:Ensembl
Biological Process lipopolysaccharide transportManual Assertion Based On ExperimentIDA:BHF-UCL
Biological Process low-density lipoprotein particle clearanceISS:BHF-UCL
Biological Process phospholipid transportISS:BHF-UCL
Biological Process plasma lipoprotein particle clearanceManual Assertion Based On ExperimentIBA:GO_Central
Biological Process positive regulation of cholesterol storageManual Assertion Based On ExperimentIDA:BHF-UCL
Biological Process positive regulation of endothelial cell migrationManual Assertion Based On ExperimentTAS:BHF-UCL
Biological Process positive regulation of nitric-oxide synthase activityManual Assertion Based On ExperimentIDA:BHF-UCL
Biological Process positive regulation of triglyceride biosynthetic processISS:BHF-UCL
Biological Process recognition of apoptotic cellManual Assertion Based On ExperimentIDA:BHF-UCL
Biological Process regulation of phagocytosis1 PublicationIC:BHF-UCL
Biological Process regulation of phosphatidylcholine catabolic processISS:BHF-UCL
Biological Process reverse cholesterol transportManual Assertion Based On ExperimentIEP:BHF-UCL
Biological Process triglyceride homeostasisISS:BHF-UCL
Biological Process vitamin transmembrane transportManual Assertion Based On ExperimentIMP:AgBase
Biological Process wound healingManual Assertion Based On ExperimentTAS:BHF-UCL
Cellular Location
Cell membrane
Membrane, caveola
Predominantly localized to cholesterol and sphingomyelin-enriched domains within the plasma membrane, called caveolae.
Topology
Cytoplasmic: 1-11
Helical: 12-32
Extracellular: 33-443
Helical: 444-464
Cytoplasmic: 465-552
PTM
N-glycosylated.
The six cysteines of the extracellular domain are all involved in intramolecular disulfide bonds.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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