Sign in or Register   Sign in or Register
  |  

Mouse Anti-SCN2A Recombinant Antibody (S69-3) (CBMAB-N4245-WJ)

This product is a Mouse antibody that recognizes SCN2A. The antibody S69-3 can be used for immunoassay techniques such as: IHC, IHC-Fr, IP, WB.
See all SCN2A antibodies
Published Data
Fig.1 Immunopurification of rat brain Nav1.2 from control and seizure animals.
...View More
Fig.2 Immunopurification of rat brain Nav1.2 from control and seizure animals.
...View More
Fig.3 Distribution of the subcellular colocalization of FGF12 and Nav1.2 channel in mammalian brain.
...View More
Fig.4 Effects of si-SCN2A vector transfection on Cu-Zn superoxide dismutase (SOD) expression and resting membrane electric potential.
...View More
Fig. 5 Lower levels of expression of SCN2A and Cu-Zn superoxide dismutase (SOD) in patients with secondary epilepsy.
...View More

Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat
Clone
S69-3
Antibody Isotype
IgG2a
Application
IHC, IHC-Fr, IP, WB

Basic Information

Specificity
Human, Mouse, Rat
Antibody Isotype
IgG2a
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.4, 50% glycerol
Concentration
1 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Sodium Voltage-Gated Channel Alpha Subunit 2
Introduction
Voltage-gated sodium channels are transmembrane glycoprotein complexes composed of a large alpha subunit with four repeat domains, each of which is composed of six membrane-spanning segments, and one or more regulatory beta subunits. Voltage-gated sodium channels function in the generation and propagation of action potentials in neurons and muscle. This gene encodes one member of the sodium channel alpha subunit gene family. Allelic variants of this gene are associated with seizure disorders and autism spectrum disorder. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2016]
Entrez Gene ID
Human6326
Mouse110876
Rat24766
UniProt ID
HumanQ99250
MouseB1AWN6
RatP04775
Alternative Names
Sodium Voltage-Gated Channel Alpha Subunit 2; Sodium Channel, Voltage-Gated, Type II, Alpha 2 Polypeptide; Sodium Channel, Voltage-Gated, Type II, Alpha 1 Polypeptide; Sodium Channel, Voltage-Gated, Type II, Alpha Subunit; Voltage-Gated Sodium Channel Subunit Alpha Nav1.2; Sodium Channel Protein Brain II Subunit Alpha; Sodium Channel Protein Type II Subunit Alpha; HBSC II; SCN2A1; SCN2A2; NAC2; Sodium Channel, Voltage Gated, Type II Alpha Subunit; Sodium Channel Protein, Brain Type 2 Alpha Subunit;
Function
Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na+ ions may pass in accordance with their electrochemical gradient (PubMed:1325650, PubMed:17021166, PubMed:28256214, PubMed:29844171).
Implicated in the regulation of hippocampal replay occurring within sharp wave ripples (SPW-R) important for memory (By similarity).
Biological Process
Biological Process cellular response to hypoxiaISS:UniProtKB
Biological Process intrinsic apoptotic signaling pathway in response to osmotic stressISS:UniProtKB
Biological Process membrane depolarization during action potentialManual Assertion Based On ExperimentIBA:GO_Central
Biological Process memoryISS:UniProtKB
Biological Process myelinationISS:BHF-UCL
Biological Process nervous system developmentISS:UniProtKB
Biological Process neuron apoptotic processISS:UniProtKB
Biological Process neuronal action potentialManual Assertion Based On ExperimentIBA:GO_Central
Biological Process regulation of ion transmembrane transportIEA:UniProtKB-KW
Biological Process sodium ion transmembrane transportISS:UniProtKB
Biological Process sodium ion transportISS:UniProtKB
Cellular Location
Cell membrane
Involvement in disease
Seizures, benign familial infantile, 3 (BFIS3):
A form of benign familial infantile epilepsy, a neurologic disorder characterized by afebrile seizures occurring in clusters during the first year of life, without neurologic sequelae. BFIS3 inheritance is autosomal dominant.
Developmental and epileptic encephalopathy 11 (DEE11):
An autosomal dominant seizure disorder characterized by neonatal or infantile onset of refractory seizures with resultant delayed neurologic development and persistent neurologic abnormalities. Patients may progress to West syndrome, which is characterized by tonic spasms with clustering, arrest of psychomotor development, and hypsarrhythmia on EEG.
Episodic ataxia 9 (EA9):
An autosomal dominant neurologic disorder characterized by episodic ataxia manifesting in the first years of life, early-onset seizures, difficulty walking, dizziness, slurred speech, headache, vomiting, and pain. The duration of ataxic episodes is heterogeneous. Most patients show episodes lasting minutes to maximum several hours, but periods lasting days up to weeks have been reported. Some patients have mildly delayed development with speech delay and/or autistic features or mildly impaired intellectual development.
PTM
May be ubiquitinated by NEDD4L; which would promote its endocytosis.
Phosphorylation at Ser-1506 by PKC in a highly conserved cytoplasmic loop slows inactivation of the sodium channel and reduces peak sodium currents.
Sumoylated at Lys-38. Sumoylation is induced by hypoxia, increases voltage-gated sodium current and mediates the early response to acute hypoxia in neurons. Sumoylated SCN2A is located at the cell membrane.
Ask a question We look forward to hearing from you.
0 reviews or Q&As

Purchasing FAQs
Technical FAQs

Loading...
Have you used Mouse Anti-SCN2A Recombinant Antibody (S69-3)?
Submit a review and get a Coupon or an Amazon gift card. 20% off Coupon $30 eGift Card
Submit a review
Loading...
For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

Online Inquiry

Documents

Contact us

  • Tel: (USA)
  • (UK)
  • Fax:
  • Email:

Submit A Review

Go to
Compare