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Mouse Anti-SCN3B Recombinant Antibody (C-11) (CBMAB-N4247-WJ)

This product is a Mouse antibody that recognizes SCN3B. The antibody C-11 can be used for immunoassay techniques such as: WB, IP, IF, ELISA.
See all SCN3B antibodies

Summary

Host Animal
Mouse
Specificity
Human, Mouse, Rat
Clone
C-11
Application
WB, IP, IF, ELISA

Basic Information

Specificity
Human, Mouse, Rat
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Sodium Voltage-Gated Channel Beta Subunit 3
Introduction
Voltage-gated sodium channels are transmembrane glycoprotein complexes composed of a large alpha subunit and one or more regulatory beta subunits. They are responsible for the generation and propagation of action potentials in neurons and muscle. This gene encodes one member of the sodium channel beta subunit gene family, and influences the inactivation kinetics of the sodium channel. Two alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008]
Entrez Gene ID
Human55800
Mouse235281
Rat245956
UniProt ID
HumanQ9NY72
MouseQ8BHK2
RatQ9JK00
Alternative Names
Sodium Voltage-Gated Channel Beta Subunit 3; Sodium Channel, Voltage-Gated, Type III, Beta Subunit; Sodium Channel, Voltage Gated, Type III Beta Subunit; Sodium Channel, Voltage-Gated, Type III, Beta; Voltage-Gated Sodium Channel Beta-3 Subunit; Sodium Channel Subunit Beta-3;
Function
Modulates channel gating kinetics. Causes unique persistent sodium currents. Inactivates the sodium channel opening more slowly than the subunit beta-1. Its association with NFASC may target the sodium channels to the nodes of Ranvier of developing axons and retain these channels at the nodes in mature myelinated axons (By similarity).
Biological Process
Biological Process atrial cardiac muscle cell action potentialManual Assertion Based On ExperimentIMP:BHF-UCL
Biological Process cardiac muscle cell action potential involved in contractionManual Assertion Based On ExperimentIMP:BHF-UCL
Biological Process cardiac muscle contractionManual Assertion Based On ExperimentIMP:BHF-UCL
Biological Process membrane depolarizationManual Assertion Based On ExperimentIDA:BHF-UCL
Biological Process membrane depolarization during action potentialManual Assertion Based On ExperimentIDA:BHF-UCL
Biological Process membrane depolarization during cardiac muscle cell action potentialManual Assertion Based On ExperimentIMP:BHF-UCL
Biological Process nervous system developmentIEA:Ensembl
Biological Process positive regulation of heart rateISS:BHF-UCL
Biological Process positive regulation of sodium ion transportManual Assertion Based On ExperimentIDA:BHF-UCL
Biological Process protein localization to plasma membraneManual Assertion Based On ExperimentIMP:BHF-UCL
Biological Process regulation of atrial cardiac muscle cell membrane depolarizationManual Assertion Based On ExperimentIMP:BHF-UCL
Biological Process regulation of heart rate by cardiac conductionManual Assertion Based On ExperimentIMP:BHF-UCL
Biological Process regulation of sodium ion transmembrane transporter activityManual Assertion Based On ExperimentIMP:BHF-UCL
Biological Process regulation of ventricular cardiac muscle cell membrane depolarizationManual Assertion Based On ExperimentIMP:BHF-UCL
Biological Process SA node cell action potentialISS:BHF-UCL
Biological Process sensory perception of painIEA:Ensembl
Biological Process sodium ion transmembrane transportManual Assertion Based On ExperimentIDA:BHF-UCL
Biological Process sodium ion transport1 PublicationNAS:UniProtKB
Biological Process ventricular cardiac muscle cell action potentialManual Assertion Based On ExperimentIMP:BHF-UCL
Cellular Location
Membrane
Involvement in disease
Brugada syndrome 7 (BRGDA7):
A tachyarrhythmia characterized by right bundle branch block and ST segment elevation on an electrocardiogram (ECG). It can cause the ventricles to beat so fast that the blood is prevented from circulating efficiently in the body. When this situation occurs, the individual will faint and may die in a few minutes if the heart is not reset.
Atrial fibrillation, familial, 16 (ATFB16):
A familial form of atrial fibrillation, a common sustained cardiac rhythm disturbance. Atrial fibrillation is characterized by disorganized atrial electrical activity and ineffective atrial contraction promoting blood stasis in the atria and reduces ventricular filling. It can result in palpitations, syncope, thromboembolic stroke, and congestive heart failure.
Topology
Extracellular: 23-159
Helical: 160-180
Cytoplasmic: 181-215
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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