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Mouse Anti-SCN8A (AA 1854-1951) Recombinant Antibody (CBXS-0155) (CBMAB-S3144-CQ)

This product is a mouse antibody that recognizes SCN8A. The antibody CBXS-0155 can be used for immunoassay techniques such as: ELISA, IF, WB.
See all SCN8A antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXS-0155
Antibody Isotype
IgG
Application
ELISA, IF, WB

Basic Information

Specificity
Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Lyophilized
Concentration
LYOPH
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.
Epitope
AA 1854-1951

Target

Full Name
sodium channel, voltage gated, type VIII, alpha subunit
Introduction
This gene encodes a member of the sodium channel alpha subunit gene family. The encoded protein forms the ion pore region of the voltage-gated sodium channel. This protein is essential for the rapid membrane depolarization that occurs during the formation of the action potential in excitable neurons. Mutations in this gene are associated with cognitive disability, pancerebellar atrophy and ataxia. Alternate splicing results in multiple transcript variants.
Entrez Gene ID
6334
UniProt ID
Q9UQD0
Alternative Names
Sodium Voltage-Gated Channel Alpha Subunit 8; Sodium Channel, Voltage Gated, Type VIII, Alpha Subunit; Voltage-Gated Sodium Channel Subunit Alpha Nav1.6; MED; Sodium Channel, Voltage Gated, Type VIII, Alpha Polypeptide; Sodium Channel, Voltage Gated, Type VIII Alpha Subunit; Voltage-Gated Sodium Channel Type VIII Alpha Protein; Sodium Channel Protein Type VIII Subunit Alpha; Sodium Channel Protein Type 8 Subunit Alpha;
Function
Mediates the voltage-dependent sodium ion permeability of excitable membranes (PubMed:29726066).
Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na+ ions may pass in accordance with their electrochemical gradient.
Isoform 5
In macrophages and melanoma cells, may participate in the control of podosome and invadopodia formation.
Biological Process
Biological Process membrane depolarization during action potentialManual Assertion Based On ExperimentIBA:GO_Central
Biological Process myelinationISS:BHF-UCL
Biological Process nervous system developmentManual Assertion Based On ExperimentTAS:ProtInc
Biological Process neuronal action potentialManual Assertion Based On ExperimentIBA:GO_Central
Biological Process peripheral nervous system developmentISS:BHF-UCL
Biological Process regulation of ion transmembrane transportIEA:UniProtKB-KW
Biological Process sodium ion transmembrane transportManual Assertion Based On ExperimentIBA:GO_Central
Biological Process sodium ion transport1 PublicationNAS:UniProtKB
Cellular Location
Cognitive impairment with or without cerebellar ataxia (CIAT):
A disorder characterized by markedly delayed cognitive and motor development, attention deficit disorder, and cerebellar ataxia. Features include bilateral esophoria, strabismatic amblyopia, unsustained gaze evoked nystagmus on horizontal gaze, ataxic gait, dysmetria in the upper limbs and dysarthria, with normal strength, tone, and reflexes.
Developmental and epileptic encephalopathy 13 (DEE13):
A form of epilepsy characterized by frequent tonic seizures or spasms beginning in infancy with a specific EEG finding of suppression-burst patterns, characterized by high-voltage bursts alternating with almost flat suppression phases. Patients may progress to West syndrome, which is characterized by tonic spasms with clustering, arrest of psychomotor development, and hypsarrhythmia on EEG. DEE13 is a severe form consisting of early-onset seizures, features of autism, intellectual disability, ataxia, and sudden unexplained death in epilepsy.
Seizures, benign familial infantile, 5 (BFIS5):
A form of benign familial infantile epilepsy, a neurologic disorder characterized by afebrile seizures occurring in clusters during the first year of life, without neurologic sequelae. BFIS5 inheritance is autosomal dominant.
Myoclonus, familial, 2 (MYOCL2):
An autosomal dominant neurologic disorder characterized by upper limb isolated myoclonus without seizures or cognitive impairment. MYOCL2 is a non-progressive disease with onset in the first decade of life.
PTM
May be ubiquitinated by NEDD4L; which would promote its endocytosis.
Phosphorylation at Ser-1497 by PKC in a highly conserved cytoplasmic loop slows inactivation of the sodium channel and reduces peak sodium currents.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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