Mouse Anti-SCNN1A (AA 617-638) Recombinant Antibody (CBFYE-0069) (CBMAB-E0156-FY)
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Basic Information
Formulations & Storage [For reference only, actual COA shall prevail!]
Target
Biological Process cellular response to aldosterone1 PublicationIC:ComplexPortal
Biological Process cellular response to amilorideManual Assertion Based On ExperimentIDA:ComplexPortal
Biological Process cellular response to vasopressin1 PublicationIC:ComplexPortal
Biological Process cellular sodium ion homeostasisManual Assertion Based On ExperimentIDA:ComplexPortal
Biological Process multicellular organismal water homeostasisManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process regulation of blood pressure1 PublicationIC:ComplexPortal
Biological Process sensory perception of salty taste1 PublicationIC:ComplexPortal
Biological Process sensory perception of sour taste1 PublicationIC:ComplexPortal
Biological Process sodium ion homeostasisManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process sodium ion import across plasma membraneManual Assertion Based On ExperimentIDA:ComplexPortal
Biological Process sodium ion transmembrane transportManual Assertion Based On ExperimentIDA:UniProtKB
Cell projection, cilium
Cytoplasmic granule
Cytoplasm
Cytoplasmic vesicle, secretory vesicle, acrosome
Cell projection, cilium, flagellum
In the oviduct and bronchus, located on cilia in multi-ciliated cells. In endometrial non-ciliated epithelial cells, restricted to apical surfaces. In epidermis, located nearly uniformly in the cytoplasm in a granular distribution (PubMed:28130590).
In sebaceous glands, observed only in the cytoplasmic space in between the lipid vesicles (PubMed:28130590).
In eccrine sweat glands, mainly located at the apical surface of the cells facing the lumen (PubMed:28130590).
In skin, in arrector pili muscle cells and in adipocytes, located in the cytoplasm and colocalized with actin fibers (PubMed:28130590).
In spermatogonia, spermatocytes and round spermatids, located in the cytoplasm (By similarity).
Prior to spermiation, location shifts from the cytoplasm to the spermatid tail (By similarity).
In spermatozoa, localizes at the acrosome and the central region of the sperm flagellum (By similarity).
A rare salt wasting disease resulting from target organ unresponsiveness to mineralocorticoids. PHA1B is a severe form involving multiple organ systems, and characterized by an often fulminant presentation in the neonatal period with dehydration, hyponatremia, hyperkalemia, metabolic acidosis, failure to thrive and weight loss.
Bronchiectasis with or without elevated sweat chloride 2 (BESC2):
A debilitating respiratory disease characterized by chronic, abnormal dilatation of the bronchi and other cystic fibrosis-like symptoms in the absence of known causes of bronchiectasis (cystic fibrosis, autoimmune diseases, ciliary dyskinesia, common variable immunodeficiency, foreign body obstruction). Clinical features include sub-normal lung function, sinopulmonary infections, chronic productive cough, excessive sputum production, and elevated sweat chloride in some cases.
Liddle syndrome 3 (LIDLS3):
A form of Liddle syndrome, an autosomal dominant disorder characterized by early onset of hypertension, hypokalemic alkalosis, and suppression of plasma renin activity and aldosterone secretion.
Helical: 86-106
Extracellular: 107-562
Helical: 563-583
Cytoplasmic: 584-669
ENaC cleavage by furin, and subsequently by prostasin (PRSS8), leads to a stepwise increase in the open probability of the channel as a result of release of the alpha and gamma subunit inhibitory tracts, respectively. Interaction of ENaC subunit SCNN1B with BPIFA1 protects ENaC against proteolytic activation.
N-glycosylated.
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Please try the standard protocols which include: protocols, troubleshooting and guide.
Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols
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Custom Antibody Labeling
We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).
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