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Mouse Anti-SCNN1B Recombinant Antibody (CBXS-2654) (CBMAB-S5407-CQ)

This product is a mouse antibody that recognizes SCNN1B. The antibody CBXS-2654 can be used for immunoassay techniques such as: WB.
See all SCNN1B antibodies

Summary

Host Animal
Mouse
Specificity
Mouse, Rat
Clone
CBXS-2654
Application
WB

Basic Information

Immunogen
Synthetic peptide corresponding to aa617-638 from rat SCNN1B at C-terminal
Specificity
Mouse, Rat
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Buffer
PBS, pH 7.4, 50% glycerol
Preservative
0.09% sodium azide
Concentration
1 mg/mL
Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
SCNN1B
Introduction
Nonvoltage-gated, amiloride-sensitive, sodium channels control fluid and electrolyte transport across epithelia in many organs. These channels are heteromeric complexes consisting of 3 subunits: alpha, beta, and gamma. This gene encodes the beta subunit, and mutations in this gene have been associated with pseudohypoaldosteronism type 1 (PHA1), and Liddle syndrome.
Entrez Gene ID
Mouse20277
Rat24767
UniProt ID
MouseQ9WU38
RatP37090
Alternative Names
Sodium Channel Epithelial 1 Beta Subunit; Sodium Channel, Non-Voltage-Gated 1, Beta Subunit; Nonvoltage-Gated Sodium Channel 1 Subunit Beta; Sodium Channel, Nonvoltage-Gated 1, Beta; Epithelial Na(+) Channel Subunit Beta; Beta-ENaC; Beta-NaCH; ENaCb; SCNEB; Amiloride-Sensitive Sodium Channel Subunit Beta 1;
Function
Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Plays an essential role in electrolyte and blood pressure homeostasis, but also in airway surface liquid homeostasis, which is important for proper clearance of mucus. Controls the reabsorption of sodium in kidney, colon, lung and sweat glands. Also plays a role in taste perception.
Biological Process
Biological Process aldosterone metabolic processIEA:Ensembl
Biological Process artery smooth muscle contractionIEA:Ensembl
Biological Process cellular response to acidic pHManual Assertion Based On ExperimentIDA:ComplexPortal
Biological Process cellular response to aldosterone1 PublicationIC:ComplexPortal
Biological Process cellular response to amilorideManual Assertion Based On ExperimentIDA:ComplexPortal
Biological Process cellular response to vasopressin1 PublicationIC:ComplexPortal
Biological Process cellular sodium ion homeostasisManual Assertion Based On ExperimentIDA:ComplexPortal
Biological Process epithelial fluid transportIEA:Ensembl
Biological Process erythrocyte homeostasisIEA:Ensembl
Biological Process gene expressionIEA:Ensembl
Biological Process leukocyte activation involved in inflammatory responseIEA:Ensembl
Biological Process mucus secretionIEA:Ensembl
Biological Process multicellular organism growthIEA:Ensembl
Biological Process multicellular organismal water homeostasisManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process neutrophil activation involved in immune responseIEA:Ensembl
Biological Process neutrophil-mediated killing of bacteriumIEA:Ensembl
Biological Process potassium ion homeostasisIEA:Ensembl
Biological Process regulation of blood pressure1 PublicationIC:ComplexPortal
Biological Process response to foodIEA:Ensembl
Biological Process response to xenobiotic stimulusIEA:Ensembl
Biological Process sensory perception of salty taste1 PublicationIC:ComplexPortal
Biological Process sensory perception of sour taste1 PublicationIC:ComplexPortal
Biological Process sodium ion homeostasisManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process sodium ion import across plasma membraneManual Assertion Based On ExperimentIDA:ComplexPortal
Biological Process sodium ion transmembrane transportManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process sodium ion transportManual Assertion Based On ExperimentTAS:ProtInc
Biological Process urea homeostasisIEA:Ensembl
Cellular Location
Apical cell membrane
Cytoplasmic vesicle membrane
Apical membrane of epithelial cells.
Involvement in disease
Pseudohypoaldosteronism 1, autosomal recessive (PHA1B):
A rare salt wasting disease resulting from target organ unresponsiveness to mineralocorticoids. PHA1B is a severe form involving multiple organ systems, and characterized by an often fulminant presentation in the neonatal period with dehydration, hyponatremia, hyperkalemia, metabolic acidosis, failure to thrive and weight loss.
Liddle syndrome 1 (LIDLS1):
A form of Liddle syndrome, an autosomal dominant disorder characterized by early onset of hypertension, hypokalemic alkalosis, and suppression of plasma renin activity and aldosterone secretion.
Bronchiectasis with or without elevated sweat chloride 1 (BESC1):
A debilitating respiratory disease characterized by chronic, abnormal dilatation of the bronchi and other cystic fibrosis-like symptoms in the absence of known causes of bronchiectasis (cystic fibrosis, autoimmune diseases, ciliary dyskinesia, common variable immunodeficiency, foreign body obstruction). Clinical features include sub-normal lung function, sinopulmonary infections, chronic productive cough, excessive sputum production, and elevated sweat chloride in some cases.
Topology
Cytoplasmic: 1-50
Helical: 51-71
Extracellular: 72-532
Helical: 533-553
Cytoplasmic: 554-640
PTM
Phosphorylated on serine and threonine residues. Aldosterone and insulin increase the basal level of phosphorylation.
N-glycosylated. N-glycosylation is required for interaction with BPIFA1.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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