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Mouse Anti-SCNN1G Monoclonal Antibody (11-35-1) (CBMAB-1144-YC)

Provided herein is a mouse monoclonal antibody against Human SCNN1G. The antibody, clone 11-35-1, can be used for immunoassay techniques, such as ELISA, ICC, IF, IHC-Fr, IHC-P and WB.
See all SCNN1G antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
11-35-1
Antibody Isotype
IgG1
Application
ELISA, ICC, IF, IHC-Fr, IHC-P, WB

Basic Information

Immunogen
Synthetic peptide seguence (VGGSIIHKAC)
Specificity
Human
Antibody Isotype
IgG1
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Format
Liquid
Purity
>95%, as determined by SDS-PAGE analysis
Storage
Store at 4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
sodium channel, nonvoltage-gated 1, gamma
Introduction
Nonvoltage-gated, amiloride-sensitive, sodium channels are heteromeric complexes consisting of 3 subunits: alpha, beta, and gamma. SCNN1G is the gamma subunit, and mutations in this gene have been associated with Liddle syndrome.
Entrez Gene ID
6340
UniProt ID
P51170
Alternative Names
PHA1; BESC3; ENaCg; SCNEG; ENaCgamma
Function
Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Plays an essential role in electrolyte and blood pressure homeostasis, but also in airway surface liquid homeostasis, which is important for proper clearance of mucus. Controls the reabsorption of sodium in kidney, colon, lung and sweat glands. Also plays a role in taste perception.
Biological Process
Biological Process cellular response to acidic pHManual Assertion Based On ExperimentIDA:ComplexPortal
Biological Process cellular response to aldosterone1 PublicationIC:ComplexPortal
Biological Process cellular response to amilorideManual Assertion Based On ExperimentIDA:ComplexPortal
Biological Process cellular response to vasopressin1 PublicationIC:ComplexPortal
Biological Process cellular sodium ion homeostasisManual Assertion Based On ExperimentIDA:ComplexPortal
Biological Process multicellular organismal water homeostasisManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process regulation of blood pressure1 PublicationIC:ComplexPortal
Biological Process sensory perception of salty taste1 PublicationIC:ComplexPortal
Biological Process sensory perception of sour taste1 PublicationIC:ComplexPortal
Biological Process sodium ion homeostasisManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process sodium ion import across plasma membraneManual Assertion Based On ExperimentIDA:ComplexPortal
Biological Process sodium ion transmembrane transportManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process sodium ion transportManual Assertion Based On ExperimentTAS:ProtInc
Cellular Location
Apical cell membrane
Apical membrane of epithelial cells.
Involvement in disease
Liddle syndrome 2 (LIDLS2):
A form of Liddle syndrome, an autosomal dominant disorder characterized by early onset of hypertension, hypokalemic alkalosis, and suppression of plasma renin activity and aldosterone secretion.
Bronchiectasis with or without elevated sweat chloride 3 (BESC3):
A debilitating respiratory disease characterized by chronic, abnormal dilatation of the bronchi and other cystic fibrosis-like symptoms in the absence of known causes of bronchiectasis (cystic fibrosis, autoimmune diseases, ciliary dyskinesia, common variable immunodeficiency, foreign body obstruction). Clinical features include sub-normal lung function, sinopulmonary infections, chronic productive cough, excessive sputum production, and elevated sweat chloride in some cases.
Pseudohypoaldosteronism 1, autosomal recessive (PHA1B):
A rare salt wasting disease resulting from target organ unresponsiveness to mineralocorticoids. PHA1B is a severe form involving multiple organ systems, and characterized by an often fulminant presentation in the neonatal period with dehydration, hyponatremia, hyperkalemia, metabolic acidosis, failure to thrive and weight loss.
Topology
Cytoplasmic: 1-55
Helical: 56-76
Extracellular: 77-541
Helical: 542-562
Cytoplasmic: 563-649
PTM
Phosphorylated on serine and threonine residues. Aldosterone and insulin increase the basal level of phosphorylation.By Similarity
Ubiquitinated; this targets individual subunits for endocytosis and proteasome-mediated degradation.
ENaC cleavage by furin, and subsequently by prostasin (PRSS8), leads to a stepwise increase in the open probability of the channel as a result of release of the alpha and gamma subunit inhibitory tracts, respectively. Interaction of ENaC subunit SCNN1B with BPIFA1 protects ENaC against proteolytic activation.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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