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Rabbit Anti-SDHAF2 Recombinant Antibody (CBXS-0174) (CBMAB-S3160-CQ)

This product is a rabbit antibody that recognizes SDHAF2. The antibody CBXS-0174 can be used for immunoassay techniques such as: WB, IP.
See all SDHAF2 antibodies

Summary

Host Animal
Rabbit
Specificity
Human, Mouse, Rat, Monkey
Clone
CBXS-0174
Application
WB, IP

Basic Information

Specificity
Human, Mouse, Rat, Monkey
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
Succinate Dehydrogenase Complex Assembly Factor 2
Introduction
This gene encodes a mitochondrial protein needed for the flavination of a succinate dehydrogenase complex subunit required for activity of the complex. Mutations in this gene are associated with paraganglioma.
Entrez Gene ID
Human54949
Mouse66072
Rat361726
Monkey693401
UniProt ID
HumanQ9NX18
MouseQ8C6I2
RatQ5RJQ7
MonkeyH9Z2F8
Alternative Names
Succinate Dehydrogenase Complex Assembly Factor 2; SDH Assembly Factor 2; C11orf79; PGL2; SDH5; Succinate Dehydrogenase Assembly Factor 2, Mitochondrial;
Function
Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SDHA of the SDH catalytic dimer.
Biological Process
Biological Process mitochondrial electron transport, succinate to ubiquinoneManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process mitochondrial respiratory chain complex II assemblyManual Assertion Based On ExperimentIBA:GO_Central
Biological Process negative regulation of canonical Wnt signaling pathwayManual Assertion Based On ExperimentIGI:MGI
Biological Process negative regulation of epithelial to mesenchymal transitionManual Assertion Based On ExperimentIMP:MGI
Biological Process protein dephosphorylationManual Assertion Based On ExperimentIGI:MGI
Biological Process protein-FAD linkageManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process tricarboxylic acid cycleManual Assertion Based On ExperimentIBA:GO_Central
Cellular Location
Mitochondrion matrix
Involvement in disease
Paragangliomas 2 (PGL2):
A neural crest tumor usually derived from the chromoreceptor tissue of a paraganglion. Paragangliomas can develop at various body sites, including the head, neck, thorax and abdomen. Most commonly, they are located in the head and neck region, specifically at the carotid bifurcation, the jugular foramen, the vagal nerve, and in the middle ear.
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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