Rabbit Anti-SDHAF2 Recombinant Antibody (CBXS-0174) (CBMAB-S3160-CQ)

Name: Rabbit Anti-SDHAF2 Recombinant Antibody (CBXS-0174)
SKU: CBMAB-S3160-CQ
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

Datasheet Target Q & As Review & reward Protocols Associated Products

Basic Information

Host Animal

Rabbit

Clone

CBXS-0174

Application

WB, IP

Specificity

Human, Mouse, Rat, Monkey

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

Succinate Dehydrogenase Complex Assembly Factor 2

Introduction

This gene encodes a mitochondrial protein needed for the flavination of a succinate dehydrogenase complex subunit required for activity of the complex. Mutations in this gene are associated with paraganglioma.

Entrez Gene ID

Human	54949
Mouse	66072
Rat	361726
Monkey	693401

UniProt ID

Human	Q9NX18
Mouse	Q8C6I2
Rat	Q5RJQ7
Monkey	H9Z2F8

Alternative Names

Succinate Dehydrogenase Complex Assembly Factor 2; SDH Assembly Factor 2; C11orf79; PGL2; SDH5; Succinate Dehydrogenase Assembly Factor 2, Mitochondrial;

Function

Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SDHA of the SDH catalytic dimer.

Biological Process

Biological Process mitochondrial electron transport, succinate to ubiquinoneManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process mitochondrial respiratory chain complex II assemblyManual Assertion Based On ExperimentIBA:GO_Central
Biological Process negative regulation of canonical Wnt signaling pathwayManual Assertion Based On ExperimentIGI:MGI
Biological Process negative regulation of epithelial to mesenchymal transitionManual Assertion Based On ExperimentIMP:MGI
Biological Process protein dephosphorylationManual Assertion Based On ExperimentIGI:MGI
Biological Process protein-FAD linkageManual Assertion Based On ExperimentIMP:UniProtKB
Biological Process tricarboxylic acid cycleManual Assertion Based On ExperimentIBA:GO_Central

Cellular Location

Mitochondrion matrix

Involvement in disease

Paragangliomas 2 (PGL2):
A neural crest tumor usually derived from the chromoreceptor tissue of a paraganglion. Paragangliomas can develop at various body sites, including the head, neck, thorax and abdomen. Most commonly, they are located in the head and neck region, specifically at the carotid bifurcation, the jugular foramen, the vagal nerve, and in the middle ear.

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme Linked Immunospot (ELISpot)
Proteogenomic
Other Protocols

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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