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Rabbit Anti-SDHC Recombinant Antibody (CBXS-1268) (CBMAB-S4127-CQ)

This product is a rabbit antibody that recognizes SDHC. The antibody CBXS-1268 can be used for immunoassay techniques such as: WB, IHC-P.
See all SDHC antibodies

Summary

Host Animal
Rabbit
Specificity
Mouse, Rat, Human
Clone
CBXS-1268
Antibody Isotype
IgG
Application
WB, IHC-P

Basic Information

Specificity
Mouse, Rat, Human
Antibody Isotype
IgG
Clonality
Monoclonal
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
succinate dehydrogenase complex, subunit C, integral membrane protein, 15kDa
Introduction
This gene encodes one of four nuclear-encoded subunits that comprise succinate dehydrogenase, also known as mitochondrial complex II, a key enzyme complex of the tricarboxylic acid cycle and aerobic respiratory chains of mitochondria. The encoded protein is one of two integral membrane proteins that anchor other subunits of the complex, which form the catalytic core, to the inner mitochondrial membrane. There are several related pseudogenes for this gene on different chromosomes. Mutations in this gene have been associated with paragangliomas. Alternatively spliced transcript variants have been described.
Entrez Gene ID
Human6391
Mouse66052
Rat289217
UniProt ID
HumanQ99643
MouseQ9CZB0
RatQ641Z9
Alternative Names
Succinate Dehydrogenase Complex Subunit C; Succinate Dehydrogenase Complex, Subunit C, Integral Membrane Protein, 15kD; Succinate-Ubiquinone Oxidoreductase Cytochrome B Large Subunit; Succinate Dehydrgenase Cytochrome B; Large Subunit Of Cytochrome B; CYB560; QPS1; CYBL; SDH3; Succinate Dehydrogenase Complex, Subunit C, Integral Membrane Protein, 15kDa;
Function
Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).
Biological Process
Biological Process aerobic respirationManual Assertion Based On ExperimentTAS:UniProtKB
Biological Process mitochondrial electron transport, succinate to ubiquinoneManual Assertion Based On ExperimentIBA:GO_Central
Biological Process proton motive force-driven mitochondrial ATP synthesis1 PublicationIC:ComplexPortal
Biological Process tricarboxylic acid cycleManual Assertion Based On ExperimentTAS:UniProtKB
Cellular Location
Mitochondrion inner membrane
Involvement in disease
Paragangliomas 3 (PGL3):
A neural crest tumor usually derived from the chromoreceptor tissue of a paraganglion. Paragangliomas can develop at various body sites, including the head, neck, thorax and abdomen. Most commonly, they are located in the head and neck region, specifically at the carotid bifurcation, the jugular foramen, the vagal nerve, and in the middle ear.
Paraganglioma and gastric stromal sarcoma (PGGSS):
Gastrointestinal stromal tumors may be sporadic or inherited in an autosomal dominant manner, alone or as a component of a syndrome associated with other tumors, such as in the context of neurofibromatosis type 1 (NF1). Patients have both gastrointestinal stromal tumors and paragangliomas. Susceptibility to the tumors was inherited in an apparently autosomal dominant manner, with incomplete penetrance.
Topology
Mitochondrial matrix: 30-62
Helical: 63-92
Mitochondrial intermembrane: 93-112
Helical: 113-137
Mitochondrial matrix: 138-144
Helical: 145-166
Mitochondrial intermembrane: 167-169
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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