Mouse Anti-SEC14L1 Recombinant Antibody (CBXS-4740) (CBMAB-S1969-CQ)

Name: Mouse Anti-SEC14L1 Recombinant Antibody (CBXS-4740)
SKU: CBMAB-S1969-CQ
Rating: 5 (1 reviews)

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Datasheet

SDS

Request for COA

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Basic Information

Host Animal

Mouse

Clone

CBXS-4740

Application

WB, IHC

Immunogen

Recombinant full length human SEC14L1 (NP_002994)

Specificity

Human

Antibody Isotype

IgG1

Application Notes

The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage

Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

More Infomation

Target

Full Name

SEC14 Like Lipid Binding 1

Introduction

The protein encoded by this gene belongs to the SEC14 cytosolic factor family. It has similarity to yeast SEC14 and to Japanese flying squid RALBP which suggests a possible role of the gene product in an intracellular transport system. Multiple alternatively spliced transcript variants have been found for this gene; some variants represent read-through transcripts that include exons from the upstream gene C17orf86.

Entrez Gene ID

6397

UniProt ID

Q92503

Alternative Names

SEC14 Like Lipid Binding 1; SEC14L; SEC14 (S. Cerevisiae)-Like 1; SEC14-Like 1 (S. Cerevisiae); SEC14-Like Lipid Binding 1; SEC14-Like Protein 1; PRELID4A;

Function

May play a role in innate immunity by inhibiting the antiviral RIG-I signaling pathway. In this pathway, functions as a negative regulator of DDX58/RIG-I, the cytoplasmic sensor of viral nucleic acids. Prevents the interaction of DDX58 with MAVS/IPS1, an important step in signal propagation (PubMed:23843640).
May also regulate the SLC18A3 and SLC5A7 cholinergic transporters (PubMed:17092608).

Biological Process

Biological Process choline transportManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process innate immune responseIEA:UniProtKB-KW
Biological Process negative regulation of RIG-I signaling pathwayManual Assertion Based On ExperimentIMP:UniProtKB

Cellular Location

Cytoplasm
Golgi apparatus

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Please try the standard protocols which include: protocols, troubleshooting and guide.

Enzyme-linked Immunosorbent Assay (ELISA)
Flow Cytometry
Immunofluorescence (IF)
Immunohistochemistry (IHC)
Immunoprecipitation (IP)
Western Blot (WB)
Enzyme-Linked Immunospot (ELISpot)
Proteogenomics
Other Protocols

Isotype control

For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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