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Mouse Anti-SEC14L1 Recombinant Antibody (CBXS-4740) (CBMAB-S1969-CQ)

This product is a mouse antibody that recognizes SEC14L1. The antibody CBXS-4740 can be used for immunoassay techniques such as: WB, IHC.
See all SEC14L1 antibodies

Summary

Host Animal
Mouse
Specificity
Human
Clone
CBXS-4740
Antibody Isotype
IgG1
Application
WB, IHC

Basic Information

Immunogen
Recombinant full length human SEC14L1 (NP_002994)
Specificity
Human
Antibody Isotype
IgG1
Application Notes
The COA includes recommended starting dilutions, optimal dilutions should be determined by the end user.

Formulations & Storage [For reference only, actual COA shall prevail!]

Storage
Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze/thaw cycles.

Target

Full Name
SEC14 Like Lipid Binding 1
Introduction
The protein encoded by this gene belongs to the SEC14 cytosolic factor family. It has similarity to yeast SEC14 and to Japanese flying squid RALBP which suggests a possible role of the gene product in an intracellular transport system. Multiple alternatively spliced transcript variants have been found for this gene; some variants represent read-through transcripts that include exons from the upstream gene C17orf86.
Entrez Gene ID
6397
UniProt ID
Q92503
Alternative Names
SEC14 Like Lipid Binding 1; SEC14L; SEC14 (S. Cerevisiae)-Like 1; SEC14-Like 1 (S. Cerevisiae); SEC14-Like Lipid Binding 1; SEC14-Like Protein 1; PRELID4A;
Function
May play a role in innate immunity by inhibiting the antiviral RIG-I signaling pathway. In this pathway, functions as a negative regulator of DDX58/RIG-I, the cytoplasmic sensor of viral nucleic acids. Prevents the interaction of DDX58 with MAVS/IPS1, an important step in signal propagation (PubMed:23843640).
May also regulate the SLC18A3 and SLC5A7 cholinergic transporters (PubMed:17092608).
Biological Process
Biological Process choline transportManual Assertion Based On ExperimentIDA:UniProtKB
Biological Process innate immune responseIEA:UniProtKB-KW
Biological Process negative regulation of RIG-I signaling pathwayManual Assertion Based On ExperimentIMP:UniProtKB
Cellular Location
Cytoplasm
Golgi apparatus
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For research use only. Not intended for any clinical use.

Custom Antibody Labeling

We also offer labeled antibodies developed using our catalog antibody products and nonfluorescent conjugates (HRP, AP, Biotin, etc.) or fluorescent conjugates (Alexa Fluor, FITC, TRITC, Rhodamine, Texas Red, R-PE, APC, Qdot Probes, Pacific Dyes, etc.).

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